Unit of Endocrinology, Department of Movement, Human and Health Sciences, Università degli Studi di Roma "Foro Italico", Piazza Lauro de Bosis 15, 00135, Roma, Italy.
Unit of Sport Medicine, Department of Movement, Human and Health Sciences, Università degli Studi di Roma "Foro Italico", Roma, Italy.
J Endocrinol Invest. 2021 Jun;44(6):1219-1228. doi: 10.1007/s40618-020-01409-z. Epub 2020 Sep 18.
Few data exist on dihydrotestosterone (DHT) adaptation to exercise-related stress. The aim of the study was to investigate on serum DHT and other androgens' responses to acute aerobic exercises, and to verify if a long-acting phosphodiesterase's type 5 inhibitors could influence these responses, as previously observed for salivary testosterone.
In a double-blind cross over study, 12 healthy trained male volunteers were submitted to both an acute sub-maximal and maximal exercise tests on cycle ergometer, after randomly receiving a two days placebo or tadalafil administration (20 mg, Cialis, Ely-Lilly, Indianapolis, IN, USA). Blood sample collections were performed at different time points before and after exercise. Serum DHT, total testosterone (TT), dehydroepiandrosterone sulfate (DHEAS) and luteinizing hormone (LH), were assayed.
Serum DHT increase in placebo treatment immediately post maximal aerobic exercise and return to basal values at 60 min of recovery whereas tadalafil administration significantly reduced the DHT increase after exercise. The values of areas under curves showed the increase of TT after acute sub-maximal and maximal exercise and of DHEAS only after acute maximal aerobic exercise independently from treatment.
In addition to testosterone, also DHT plays an exercise-related adaptive role during high intensity aerobic exercise, but its rapid useful effects during exercise have to be determined. We hypothesized that the increased androgens secretion during exercise could be mainly related to steroidogenic enzymes modifications in peripheral tissues (i.e., muscles). Moreover, the blunting effect of tadalafil on DHT increase support a possible role of peripheral nitric oxide/GMPc related pathways in influencing physical-stress related DHT metabolism.
关于双氢睾酮（DHT）对与运动相关的应激的适应的数据很少。本研究的目的是研究血清 DHT 和其他雄激素对急性有氧运动的反应，并验证长效磷酸二酯酶 5 型抑制剂是否会影响这些反应，就像以前观察唾液睾酮一样。
在一项双盲交叉研究中，12 名健康的训练有素的男性志愿者在随机接受两天安慰剂或他达拉非（20mg，Cialis，Ely-Lilly，印第安纳波利斯，IN，USA）治疗后，分别接受了急性亚最大和最大运动测试。在运动前后的不同时间点采集血液样本。检测血清 DHT、总睾酮（TT）、脱氢表雄酮硫酸盐（DHEAS）和黄体生成素（LH）。
在最大有氧运动后，安慰剂治疗组血清 DHT 立即增加，并在恢复 60 分钟时恢复到基础值，而他达拉非治疗组显著降低了运动后 DHT 的增加。曲线下面积的值显示，急性亚最大和最大有氧运动后 TT 增加，而仅在急性最大有氧运动后 DHEAS 增加，与治疗无关。
除了睾酮外，DHT 在高强度有氧运动中也发挥着与运动相关的适应性作用，但它在运动中的快速作用还需要确定。我们假设，运动期间雄激素分泌的增加可能主要与外周组织（即肌肉）中类固醇生成酶的改变有关。此外，他达拉非对 DHT 增加的抑制作用支持外周一氧化氮/GMPc 相关途径在影响与物理应激相关的 DHT 代谢中的可能作用。
