Sgrò P, Romanelli F, Felici F, Sansone M, Bianchini S, Buzzachera C F, Baldari C, Guidetti L, Pigozzi F, Lenzi A, Di Luigi L
Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", Piazza Lauro de Bosis, 15, 00135, Rome, Italy.
J Endocrinol Invest. 2014 Jan;37(1):13-24. doi: 10.1007/s40618-013-0006-0. Epub 2014 Jan 8.
Few and conflicting data on the acute adaptive role of the hypothalamic-pituitary-testicular (HPT) axis to sub-maximal endurance exercise exist.
To investigate the acute HPT axis responses to standardized endurance exercises in a laboratory setting and the correlations between testosterone and classic adaptive hormones variations.
12 healthy male volunteers were recruited for this experimental study. Serum PRL, GH, ACTH, LH, cortisol, DHEAS, testosterone [total (TT), calculated free (cFT) and bioavailable (cBioT)], SHBG, and respective ratios, were evaluated before and after a 30-min sub-maximal exercise on cycle ergometer at individual anaerobic threshold (IAT) and a maximal exercise until exhaustion. Blood samples were collected before exercise (30, 15 min and immediately before), immediately after and at different time points during recovery (+15, +30 and +60 min) for hormones assays. Oxygen consumption and lactate concentration were evaluated.
Testosterone (TT, cFT and cBioT) acutely increased in all volunteers after both exercises. Testosterone increased in parallel to GH after both exercises and to cortisol only after maximal exercise. Differently from other increased hormones, testosterone increases were not correlated to exercise-intensity-related variables. The anabolic/catabolic steroids ratios were higher after sub-maximal exercise, compared to maximal.
A 30-min sub-maximal endurance exercise acutely increased serum testosterone similarly to maximal exercise, but without cortisol increases. Exercise-related testosterone peaks should be considered adaptive phenomena, but few data on their short- and long-term effects exist. Investigations on the mechanisms of adaptation to exercise in active individuals with physiological or pathological hypo-testosteronemia are warranted.
关于下丘脑 - 垂体 - 睾丸（HPT）轴对次最大耐力运动的急性适应性作用的数据很少且相互矛盾。
在实验室环境中研究HPT轴对标准化耐力运动的急性反应，以及睾酮与经典适应性激素变化之间的相关性。
招募12名健康男性志愿者进行本实验研究。在个体无氧阈（IAT）下进行30分钟次最大运动和直至 exhaustion 的最大运动前后，评估血清催乳素（PRL）、生长激素（GH）、促肾上腺皮质激素（ACTH）、促黄体生成素（LH）、皮质醇、硫酸脱氢表雄酮（DHEAS）、睾酮[总睾酮（TT）、计算游离睾酮（cFT）和生物可利用睾酮（cBioT）]、性激素结合球蛋白（SHBG）以及各自的比值。在运动前（30分钟、15分钟和即将运动前）、运动后即刻以及恢复期间的不同时间点（+15分钟、+30分钟和+60分钟）采集血样进行激素检测。评估耗氧量和乳酸浓度。
两次运动后所有志愿者的睾酮（TT、cFT和cBioT）均急性升高。两次运动后睾酮均与GH平行升高，仅在最大运动后与皮质醇平行升高。与其他升高的激素不同，睾酮的升高与运动强度相关变量无关。与最大运动相比，次最大运动后合成代谢/分解代谢类固醇比值更高。
30分钟次最大耐力运动与最大运动一样能使血清睾酮急性升高，但不会使皮质醇升高。运动相关的睾酮峰值应被视为适应性现象，但关于其短期和长期影响的数据很少。有必要对生理或病理性低睾酮血症的活跃个体运动适应机制进行研究。
