Department of Emergency Medicine, Tokat Gaziosmanpaşa University Faculty of Medicine, Tokat-Turkey.
Department of General Surgery, Tokat Gaziosmanpaşa University Faculty of Medicine, Tokat-Turkey.
Ulus Travma Acil Cerrahi Derg. 2020 Sep;26(5):760-764. doi: 10.14744/tjtes.2020.47973.
This study aimed to investigate the superiority of C-reactive protein (CRP) lymphocyte ratio (CLR) in acute appendicitis (AA) and perforated appendicitis (PA) compared to routine laboratory parameters in patients where radiological tests were insufficient to clarify the diagnosis.
In this cross-sectional and retrospective study, the patients were divided into two groups as PA and AA. Age, sex, length of hospital stay, leukocytes, neutrophil, lymphocyte, CRP, and CLR were recorded at the time of diagnosis. Regression analyses were performed for the parameters, which were found to be statistically significant in univariate analysis.
One hundred thirty-one patients were included in this study (111 patients in the AA group, and 20 patients in the PA group). Age (p=0.03), gender (p<0.001), length of hospital stay (p<0.001), CRP (p<0.001), NLR (p=0.004) and CLR (p<0.001) were significantly different between both groups. However, only CLR was found as a significant risk factor in PA cases (p=0.016). The ROC analysis showed the highest AUC value in CLR (0.83). The cut-off value for predicting PA was found 0.45.
This study provided that the CLR is an important parameter for the differentiation of AA and PA patients. Besides, it is a valuable predictor in the preoperative risk classification of these patients.
本研究旨在探讨 C-反应蛋白（CRP）与淋巴细胞比值（CLR）在影像学检查不足以明确诊断的急性阑尾炎（AA）和穿孔性阑尾炎（PA）患者中的优势，优于常规实验室参数。
在这项横断面和回顾性研究中，将患者分为 PA 和 AA 两组。在诊断时记录年龄、性别、住院时间、白细胞、中性粒细胞、淋巴细胞、CRP 和 CLR。对单因素分析中具有统计学意义的参数进行回归分析。
本研究共纳入 131 例患者（AA 组 111 例，PA 组 20 例）。两组间年龄（p=0.03）、性别（p<0.001）、住院时间（p<0.001）、CRP（p<0.001）、NLR（p=0.004）和 CLR（p<0.001）均有显著差异。然而，只有 CLR 被发现是 PA 病例的显著危险因素（p=0.016）。ROC 分析显示 CLR 的 AUC 值最高（0.83）。预测 PA 的截断值为 0.45。
本研究表明，CLR 是区分 AA 和 PA 患者的重要参数。此外，它是这些患者术前风险分类的有价值的预测指标。
