Pettersson Nina, Kragsbjerg Fredrik, Hamrin Arvid, Bergman Stefan, Forsblad-d'Elia Helena, Karling Pontus
Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
Department of Medicine, Sundsvall-Härnösand Hospital, Sundsvall, Sweden.
Scand J Gastroenterol. 2020 Oct;55(10):1193-1199. doi: 10.1080/00365521.2020.1820567. Epub 2020 Sep 18.
BACKGROUNDS/AIMS: Musculoskeletal symptoms are common in patients with ulcerative colitis (UC), but no study has compared the prevalence of chronic pain to controls from a general population.
Patients with UC ( = 1164) and controls ( = 3867) were sent questionnaires comprising demography, history of pain, pain localization and UC patients' Patient-Simple Clinical Colitis Activity Index. Chronic regional pain (ChRP) and chronic widespread pain (ChWP) were defined as having pain for at least 3 months.
The response rate for the patients with UC was 49.0% and for the control persons 61.7% ( < .001). The reported prevalence of ChRP and ChWP was higher in patients with UC versus controls (33.1% vs. 24.2%; < .001 and 19.8% vs. 12.5%; < .001). The patients with UC reported significantly more pain in the regions 'lower back', 'hip/upper leg' and 'lower leg/foot' compared to controls. The patients with P-SCCAI 5 ( = 121) reported more ChWP than patients with P-SCCAI <5 ( = 426) (46.3% vs. 12.7%; < .001) and controls ( = 2425) (46.3 vs. 12.5%; < .001) in all body regions. No significant difference in ChWP was found between patients with P-SCCAI <5 and controls (12.7% vs. 12.5%; = .917).
Patients with UC reported more chronic pain than controls from the general population, especially from the lower back and hip region. Higher UC disease activity was associated with more pain in all body regions.
背景/目的：肌肉骨骼症状在溃疡性结肠炎（UC）患者中很常见，但尚无研究将慢性疼痛的患病率与普通人群的对照组进行比较。
向UC患者（n = 1164）和对照组（n = 3867）发送问卷，内容包括人口统计学、疼痛史、疼痛部位以及UC患者的患者简易临床结肠炎活动指数。慢性局部疼痛（ChRP）和慢性广泛性疼痛（ChWP）定义为疼痛至少持续3个月。
UC患者的回复率为49.0%，对照组为61.7%（P <.001）。UC患者中ChRP和ChWP的报告患病率高于对照组（33.1%对24.2%；P <.001和19.8%对12.5%；P <.001）。与对照组相比，UC患者报告在“下背部”、“臀部/大腿上部”和“小腿/足部”区域疼痛明显更多。P-SCCAI≥5的患者（n = 121）报告的ChWP比P-SCCAI <5的患者（n = 426）（46.3%对12.7%；P <.001）和对照组（n = 2425）（46.3%对12.5%；P <.001）在所有身体区域都更多。P-SCCAI <5的患者和对照组之间在ChWP方面未发现显著差异（12.7%对12.5%；P =.917）。
UC患者报告的慢性疼痛比普通人群的对照组更多，尤其是下背部和臀部区域。更高的UC疾病活动度与所有身体区域更多的疼痛相关。
