Yang Chunchun, Zhang Xueli, Wang Suming, Huo Xiaohui, Wang Jing
Gastroenterology Department, The First Hospital of Hebei Medical University Shijiazhuang, Hebei, China.
Am J Transl Res. 2021 Jun 15;13(6):6605-6610. eCollection 2021.
To investigate the small intestinal bacterial overgrowth (SIBO) and to evaluate the intestinal barrier function in ulcerative colitis (UC) patients treated with mesalazine and rifaximin.
96 patients undergoing the methane-hydrogen breath test in our hospital from January 2018 to January 2020 were enrolled in the study group, and 40 healthy persons were enrolled in the control group during this period. The SIBO positive rate of the two groups were collected and compared. Then, the SIBO positive patients were divided into group A and group B. Group A and group B all received mesalazine, and group B received rifaximin plus. The clinical efficacy, erythrocyte sedimentation rate (ESR), C reactive protein (CRP), and intestinal barrier function indexes like diamine oxidase (DAO) and D-lactic acid (DLA) were recorded and compared.
The study group presented higher SIBO positive rate compared with the control group (56% vs. 25%, P<0.05). After treatment, group B showed better clinical efficacy and lower levels of ESR and CRP than group A (all P<0.05). After treatment, the DAO and D-LA levels of the two groups were decreased, and presented lower levels in group B than group A (all P<0.05).
UC patients present a higher positive rate in SIBO. Mesalazine and rifaximin are applied to patients with mild to moderate UC, and their clinical efficacy has been significantly enhanced after the eradication of SIBO.
探讨溃疡性结肠炎（UC）患者小肠细菌过度生长（SIBO）情况，并评估美沙拉嗪和利福昔明治疗UC患者的肠道屏障功能。
选取2018年1月至2020年1月在我院行甲烷-氢气呼气试验的96例患者作为研究组，同期选取40例健康者作为对照组。收集并比较两组的SIBO阳性率。然后，将SIBO阳性患者分为A组和B组。A组和B组均接受美沙拉嗪治疗，B组加用利福昔明。记录并比较两组的临床疗效、红细胞沉降率（ESR）、C反应蛋白（CRP）以及二胺氧化酶（DAO）和D-乳酸（DLA）等肠道屏障功能指标。
研究组SIBO阳性率高于对照组（56%比25%，P<0.05）。治疗后，B组临床疗效优于A组，ESR和CRP水平低于A组（均P<0.05）。治疗后，两组DAO和D-LA水平均降低，且B组低于A组（均P<0.05）。
UC患者SIBO阳性率较高。美沙拉嗪和利福昔明应用于轻至中度UC患者，根除SIBO后临床疗效显著提高。
