肠道微生物组在免疫代谢中的作用。

The Gut Microbiota at the Service of Immunometabolism.

机构信息

INRA, UMR1319 Micalis and AgroParisTech, Jouy en Josas, France; Paris Center for Microbiome Medicine (PaCeMM) FHU, Paris, France.

INRA, UMR1319 Micalis and AgroParisTech, Jouy en Josas, France; Paris Center for Microbiome Medicine (PaCeMM) FHU, Paris, France; Sorbonne Université, INSERM, Centre de Recherche Saint-Antoine, CRSA, AP-HP, Saint Antoine Hospital, Gastroenterology Department, 75012 Paris, France.

出版信息

Cell Metab. 2020 Oct 6;32(4):514-523. doi: 10.1016/j.cmet.2020.09.004. Epub 2020 Sep 17.

DOI:10.1016/j.cmet.2020.09.004

PMID:32946809

Abstract

The gut microbiota is implicated in immune system functions. Regulation of the metabolic processes occurring in immune cells is crucial for the maintenance of homeostasis and immunopathogenesis. Emerging data demonstrate that the gut microbiota is an actor in immunometabolism, notably through the effect of metabolites such as short-chain fatty acids, bile acids, and tryptophan metabolites. In this Perspective, we discuss the impact of the gut microbiota on the intracellular metabolism of the different subtypes of immune cells, including intestinal epithelial cells. Besides the effects on health, we discuss the potential consequences in infection context and inflammatory bowel diseases.

摘要

肠道微生物群与免疫系统功能有关。调节免疫细胞中发生的代谢过程对于维持体内平衡和免疫发病机制至关重要。新出现的数据表明，肠道微生物群是免疫代谢的一个因素，特别是通过短链脂肪酸、胆汁酸和色氨酸代谢物等代谢物的影响。在本观点中，我们讨论了肠道微生物群对不同类型免疫细胞（包括肠道上皮细胞）的细胞内代谢的影响。除了对健康的影响外，我们还讨论了在感染和炎症性肠病情况下的潜在后果。