肠道微生物衍生代谢物在宿主免疫反应及免疫相关性炎症性疾病中的调控作用。
Gut microbiota-derived metabolites in the regulation of host immune responses and immune-related inflammatory diseases.
机构信息
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.
出版信息
Cell Mol Immunol. 2021 Apr;18(4):866-877. doi: 10.1038/s41423-021-00661-4. Epub 2021 Mar 11.
Abstract
The gut microbiota has a critical role in the maintenance of immune homeostasis. Alterations in the intestinal microbiota and gut microbiota-derived metabolites have been recognized in many immune-related inflammatory disorders. These metabolites can be produced by gut microbiota from dietary components or by the host and can be modified by gut bacteria or synthesized de novo by gut bacteria. Gut microbiota-derived metabolites influence a plethora of immune cell responses, including T cells, B cells, dendritic cells, and macrophages. Some of these metabolites are involved in the pathogenesis of immune-related inflammatory diseases, such as inflammatory bowel diseases, diabetes, rheumatoid arthritis, and systemic lupus erythematosus. Here, we review the role of microbiota-derived metabolites in regulating the functions of different immune cells and the pathogenesis of chronic immune-related inflammatory diseases.
摘要
肠道微生物群在维持免疫稳态方面起着关键作用。在许多与免疫相关的炎症性疾病中，已经认识到肠道微生物群和肠道微生物群衍生代谢物的改变。这些代谢物可以由肠道微生物群从饮食成分中产生，也可以由宿主产生，并且可以被肠道细菌修饰或由肠道细菌从头合成。肠道微生物群衍生的代谢物影响多种免疫细胞的反应，包括 T 细胞、B 细胞、树突状细胞和巨噬细胞。其中一些代谢物参与与免疫相关的炎症性疾病的发病机制，如炎症性肠病、糖尿病、类风湿关节炎和系统性红斑狼疮。在这里，我们综述了微生物群衍生代谢物在调节不同免疫细胞功能和慢性与免疫相关的炎症性疾病发病机制中的作用。
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