Department of Dermatology, Mayo Clinic, Scottsdale, Arizona.
Westlake Dermatology & Cosmetic Surgery, Dallas, Texas.
Dermatol Surg. 2020 Dec;46(12):1715-1720. doi: 10.1097/DSS.0000000000002709.
Foam sclerotherapy is a common treatment of lower extremity reticular veins. The effect of different liquid-gas ratios on foam stability and efficacy has been controversial.
To evaluate the use of 2 different polidocanol (POL) to air ratios for the treatment of reticular veins of the lower extremities.
Patients with lower extremity reticular veins were randomized to foam sclerotherapy with POL mixed with 4 mL of room air for one lower extremity or 2 mL for the other lower extremity. All telangiectasias were treated with glycerin immediately after treatment of the reticular veins. Adverse events (AEs) and efficacy were evaluated by both subject and blinded investigator.
Thirty subjects completed the study. No statistically significant difference was seen in AEs between the 2 different POL to air ratios by subject questionnaire and blinded investigator scores at all time points. Subjects and blinded investigator reported a mean improvement between 0% and 50% at Day 21 and 26% to 75% at Day 90, which was not significantly different between groups.
Two different POL to air ratios, 1:2 versus 1:4, were similarly safe and efficacious for the treatment reticular veins of the lower extremities.
泡沫硬化疗法是治疗下肢网状静脉的常用方法。不同液气比的泡沫稳定性和疗效一直存在争议。
评估 2 种不同的聚多卡醇（POL）与空气的比例用于治疗下肢网状静脉。
下肢网状静脉患者随机分为泡沫硬化疗法，一侧下肢用 POL 混合 4 毫升空气，另一侧下肢用 2 毫升空气。所有毛细血管扩张症在治疗网状静脉后立即用甘油治疗。不良事件（AEs）和疗效由患者和盲法研究者评估。
30 名患者完成了研究。在所有时间点，通过患者问卷和盲法研究者评分，两种不同的 POL 与空气比例之间的不良事件无统计学差异。患者和盲法研究者报告在第 21 天和第 90 天分别有 0%至 50%和 26%至 75%的平均改善，组间无显著差异。
对于治疗下肢网状静脉，1:2 与 1:4 两种不同的 POL 与空气比例同样安全有效。
