Clinical Laboratory Center, Wuyi First People's Hospital, Wuyi, Jinhua, 321200, Zhejiang, China.
Wuyi First People's Hospital, Wuyi, Jinhua, 321200, Zhejiang, China.
BMC Infect Dis. 2020 Sep 18;20(1):687. doi: 10.1186/s12879-020-05420-w.
Vogesella species are common aquatic, Gram-negative rod-shaped bacteria, originally described in 1997. Vogesella perlucida was first isolated from spring water in 2008. Furthermore, bacterial pathogenicity of Vogesella perlucida has never been reported. Here, we report the first case of rare Vogesella perlucida-induced bacteremia in an advanced-age patient with many basic diseases and history of dexamethasone abuse.
A 71-year-old female was admitted with inflamed upper and lower limbs, rubefaction, pain and fever (about 40 °C). She had been injured in a fall at a vegetable market and then touched river snails with her injury hands. A few days later, soft tissue infection of the patient developed and worsened. Non-pigmented colonies were isolated from blood cultures of the patient. Initially, Vogesella perlucida was wrongly identified as Sphingomonas paucimobilis by Vitek-2 system with GN card. Besides, we failed to obtain an acceptable identification by the MALDI-TOF analysis. Finally, the isolated strain was identified as Vogesella perlucida by 16S rRNA gene sequences. In addition, the patient recovered well after a continuous treatment of levofloxacin for 12 days.
Traditional microbiological testing system may be inadequate in the diagnosis of rare pathogenic bacteria. Applications of molecular diagnostics techniques have great advantages in clinical microbiology laboratory. By using 16S rRNA gene sequence analysis, we report the the first case of rare Vogesella perlucida-induced bacteremia.
Vogesella 属是常见的水生革兰氏阴性杆菌，最初于 1997 年描述。Vogesella perlucida 于 2008 年首次从泉水分离得到。此外，Vogesella perlucida 的细菌致病性从未被报道过。在此，我们报道了首例罕见的 Vogesella perlucida 引起的菌血症，患者为高龄，患有多种基础疾病且有滥用地塞米松的病史。
一名 71 岁女性因发热、上下肢红肿、疼痛就诊（约 40℃）。她曾在菜市场摔倒受伤，然后用受伤的手触摸河螺。几天后，患者出现软组织感染且病情加重。从患者的血培养中分离出非色素菌落。最初，Vitek-2 系统 GN 卡误将 Vogesella perlucida 鉴定为 Sphingomonas paucimobilis。此外，MALDI-TOF 分析也无法得到满意的鉴定结果。最终，通过 16S rRNA 基因序列鉴定出该分离株为 Vogesella perlucida。此外，患者经左氧氟沙星连续治疗 12 天后痊愈。
传统的微生物学检测系统可能不足以诊断罕见的病原体。分子诊断技术在临床微生物学实验室中有很大的优势。通过使用 16S rRNA 基因序列分析，我们报告了首例罕见的 Vogesella perlucida 引起的菌血症。
