Geriatric Cardiology Clinic, Cardiology Division, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
Elderly Vulnerability Disease Research Group-Cardiology Division, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
Eur J Clin Nutr. 2021 Mar;75(3):446-455. doi: 10.1038/s41430-020-00753-w. Epub 2020 Sep 18.
To characterize the phenotypes of older adults with low lean mass and osteoporosis, concomitantly or isolated, in regards to poor physical performance and frailty status.
Cross-sectional analysis of the SARCopenia and OSteoporosis in Older Adults with Cardiovascular Diseases Study (SARCOS).
Outpatient geriatric cardiology clinic.
385 older adults underwent DXA analysis. Low lean mass was diagnosed according to FNIH and low BMD by a T-score ≤ -2.5 SD. Subjects were grouped into: I-Low lean mass and Osteoporosis (LLMO); II-Low lean mass (LLM); III-Osteoporosis (OP), and IV-Controls. Poor physical performance was diagnosed by weakness or slow walking speed or impaired mobility. Frailty was diagnosed by CHS criteria.
The mean age was 78.22 ± 7.16 years. The prevalence of LLMO, LLM, and OP were 14.8%, 39.5%, and 19.2%, respectively. LLMO subjects were older, predominantly women, with a high percentage of body fat (HTBF). LLM was represented by obese men, while individuals with OP were preferably women, older and leaner. In a regression analyses, LLMO presented an OR: 6.42 (2.63‒15.65; p < 0.001) for weakness, OR: 2.55 (1.09‒5.95; p = 0.030) for impaired mobility, and OR: 14.75 (2.72‒79.94; p = 0.002) for frailty. After adjusting for HTBF, the OR for frailty, decreased to 7.25 (1.11-47.21; p = 0.038). LLM and OP were associated only with weakness with an OR: 3.06 (1.36-6.84; p = 0.006) and OR: 3.14 (1.29-7.62; p = 0.011), respectively.
In Brazilian older community-dwelling outpatient adults, the phenotype characterized by low lean mass and osteoporosis presents a higher association with impaired mobility, weakness and frailty status compared to the others phenotyeps and controls. A high percentage of body fat presents a synergistic effect with low lean mass and osteoporosis phenotype in regards to frailty.
描述同时或单独存在低瘦体重和骨质疏松症的老年患者的表型，这些患者的身体机能较差且患有衰弱症。
心血管疾病老年患者的肌肉减少症和骨质疏松症研究（SARCOS）的横断面分析。
门诊老年心脏病学诊所。
385 名老年人接受了 DXA 分析。根据 FNIH 和 T 评分≤-2.5 SD 诊断低瘦体重。受试者分为：I-低瘦体重和骨质疏松症（LLMO）；II-低瘦体重（LLM）；III-骨质疏松症（OP）和 IV-对照组。身体机能较差通过肌力减弱、行走速度缓慢或活动能力受损来诊断。衰弱症通过 CHS 标准来诊断。
平均年龄为 78.22±7.16 岁。LLMO、LLM 和 OP 的患病率分别为 14.8%、39.5%和 19.2%。LLMO 组患者年龄较大，多数为女性，体脂百分比较高（HTBF）。LLM 主要表现为肥胖男性，而 OP 患者则多为女性，年龄较大且瘦体重较低。在回归分析中，LLMO 表现出的肌肉减弱的比值比（OR）为 6.42（2.63-15.65；p<0.001），活动能力受损的 OR 为 2.55（1.09-5.95；p=0.030），衰弱症的 OR 为 14.75（2.72-79.94；p=0.002）。调整 HTBF 后，衰弱症的 OR 降至 7.25（1.11-47.21；p=0.038）。LLM 和 OP 仅与肌肉减弱相关，OR 分别为 3.06（1.36-6.84；p=0.006）和 3.14（1.29-7.62；p=0.011）。
在巴西社区门诊的老年患者中，与其他表型和对照组相比，同时存在低瘦体重和骨质疏松症的表型与活动能力受损、肌肉减弱和衰弱状态的相关性更高。高体脂百分比与低瘦体重和骨质疏松症表型对衰弱症有协同作用。
