Department of Geriatric Medicine, Dokuz Eylul University, Faculty of Medicine, Izmir, Turkey.
Department of Geriatric Medicine, Dokuz Eylul University, Faculty of Medicine, Izmir, Turkey; Geriatric Center, Kayseri Education and Research Hospital, Kayseri, Turkey.
Exp Gerontol. 2017 Sep;95:136-140. doi: 10.1016/j.exger.2017.05.017. Epub 2017 May 23.
Sarcopenia and dynapenia are related to repeated falls, mobility restriction, depression, frailty, increased mortality and morbidity. The aim of this study is to evaluate the relationship between vitamin B12 deficiency and sarcopenia in older adults. 403 patients, who attended to outpatient clinic and underwent comprehensive geriatric assessment, were included study. All cases' skeletal muscle mass (SMM), walking speed and hand grip strength were recorded by bioimpedance, 4meter walking test and hand dynamometer respectively. The diagnosis of sarcopenia was defined according to the criteria of the European Working Group on Sarcopenia in Older People. Sarcopenia was accepted low SMM with low handgrip strength or low physical performance. Dynapenia was defined as handgrip strength <30kg (men) and <20kg (women). The prevalence of sarcopenia and dynapenia was 24.8% and 32.0%, respectively. In the patients with sarcopenia, mean age, osteoporosis and frailty were higher, and MMSE, and instrumental ADL scores were lower than the patients without sarcopenia (p<0.05). The frequency of sarcopenia and dynapenia were 31.6% and 35.4%, respectively, in patients with vitamin B12 levels <400pg/mL. In addition lean body mass, total skeletal mass and skeletal muscle mass index were lower in the patients with vitamin B12 levels <400pg/mL compared to higher than 400pg/mL (p<0.05). Sarcopenia, which results in lots of negative clinical outcomes in older adults, might be related to vitamin B12 deficiency. Therefore, these patients should be periodically examined for vitamin B12 deficiency due to the potential negative clinical outcomes such as sarcopenia in older adults.
肌肉减少症和力量下降与反复跌倒、活动受限、抑郁、虚弱、死亡率和发病率增加有关。本研究旨在评估老年人维生素 B12 缺乏与肌肉减少症之间的关系。共纳入 403 名在门诊就诊并接受全面老年评估的患者。所有患者的骨骼肌质量（SMM）、步行速度和手握力均通过生物电阻抗、4 米步行测试和握力计分别记录。肌肉减少症的诊断根据欧洲老年人肌肉减少症工作组的标准定义。肌肉减少症被认为是低 SMM 伴低握力或低身体表现。力量下降定义为握力<30kg（男性）和<20kg（女性）。肌肉减少症和力量下降的患病率分别为 24.8%和 32.0%。在肌肉减少症患者中，平均年龄、骨质疏松症和虚弱程度较高，而 MMSE 和工具性日常生活活动评分较低（p<0.05）。维生素 B12 水平<400pg/mL 的患者中，肌肉减少症和力量下降的发生率分别为 31.6%和 35.4%。此外，与维生素 B12 水平>400pg/mL 的患者相比，维生素 B12 水平<400pg/mL 的患者的瘦体重、总骨骼质量和骨骼肌质量指数较低（p<0.05）。肌肉减少症会导致老年人出现许多负面的临床后果，可能与维生素 B12 缺乏有关。因此，这些患者应定期检查维生素 B12 缺乏，因为维生素 B12 缺乏可能导致老年人出现肌肉减少症等潜在的负面临床后果。
