Menzies School of Health Research, Charles Darwin University, NT 0810, Australia; Institute for Social Science Research, The University of Queensland, Brisbane, Australia.
Mater Clinical School, The University of Queensland, Brisbane, Australia; Mater Medical Research Institute, Raymond Tce, South Brisbane, Qld 4101, Australia.
Atherosclerosis. 2020 Oct;311:91-97. doi: 10.1016/j.atherosclerosis.2020.09.001. Epub 2020 Sep 6.
The early life predictors of changes in the blood pressures of offspring between childhood and young adulthood have not been well defined. Thus, this study aimed to determine the life course association of offspring's blood pressure with prenatal and early infancy lifestyle, and other factors taking advantage of a large community-based, longitudinal study of a birth cohort in Australia - the MUSP study.
The systolic and diastolic blood pressure (SBP, DBP) was measured for 3793, 3782, 2628 and 1780 offspring of the Australian longitudinal cohort study at 5, 14, 21 and 30 years of their age, respectively. Individual PP and mean arterial pressure (MAP) was equated, and Generalized Estimating Equations with time (age) and predictor interaction modelling were performed.
Blood pressures of the offspring increased significantly between 5 and 30 years. Early life factors such as pre-pregnancy overweight/obesity, and hypertensive disorder in pregnancy were significantly positively associated, and duration of gestation and pre-pregnancy thinness of the mothers negatively associated with this life course increase in the offspring's blood pressure. Rapid increase in body weight from birth to 5 years had a strong association with increasing blood pressures components throughout their life course.
Several maternal pre-pregnancy and pregnancy factors along with the early life growth characteristics of offspring are important predictors of increase in blood pressure of the offspring from their childhood to adulthood.
儿童期到青年期，后代血压变化的早期生命预测因素尚未明确。因此，本研究旨在利用澳大利亚一项基于社区的大型队列研究（MUSP 研究），确定后代血压与产前和婴儿早期生活方式及其他因素的生命历程关联。
对澳大利亚纵向队列研究的 3793、3782、2628 和 1780 名后代，分别在其 5、14、21 和 30 岁时测量收缩压和舒张压（SBP、DBP）。个体脉压和平均动脉压（MAP）相等，并进行时间（年龄）和预测因子交互模型的广义估计方程分析。
后代的血压在 5 至 30 岁之间显著升高。早期生活因素，如妊娠前超重/肥胖和妊娠高血压疾病与后代血压的这种生命历程增加呈显著正相关，而母亲的妊娠前消瘦和妊娠时间与后代血压的生命历程增加呈负相关。从出生到 5 岁期间体重的快速增长与整个生命历程中血压成分的升高有很强的关联。
母亲妊娠前和妊娠期间的多种因素以及后代的早期生命生长特征是后代从儿童期到成年期血压升高的重要预测因素。
