使用双通道光泵磁力仪传感器检测和分析枕叶区域的脑磁图信号。
Detection and analysis of MEG signals in occipital region with double-channel OPM sensors.
作者信息
Zhang Xin, Chen Chun-Qiao, Zhang Ming-Kang, Ma Chang-Yu, Zhang Yin, Wang Hui, Guo Qing-Qian, Hu Tao, Liu Zhao-Bang, Chang Yan, Hu Ke-Jia, Yang Xiao-Dong
机构信息
School of Biomedical Engineering (Suzhou), Division of Life Science and Medicine, University of Science and Technology of China, Hefei, 230026, China; Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, 215163, China; Jihua Laboratory, Foshan, 528000, China.
Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, 215163, China; Jihua Laboratory, Foshan, 528000, China; Changchun University of Science and Technology, Changchun, 130022, China.
出版信息
J Neurosci Methods. 2020 Dec 1;346:108948. doi: 10.1016/j.jneumeth.2020.108948. Epub 2020 Sep 17.
BACKGROUND
Magnetoencephalography (MEG) has high temporal and spatial resolution and good spatial accuracy in determining the locations of source activity among most non-invasive imaging. The recently developed technology of optically-pumped magnetometer (OPM) has sensitivity comparable to that of the superconducting quantum interference device (SQUID) used in commercial MEG system.
NEW METHOD
Double-channel OPM-MEG system detects human photic blocking of alpha rhythm at the occipital region of skull in the magnetically shielded environment via a wearable whole-cortex 3D-printed helmet.
RESULTS
The alpha rhythm can be detected by the OPM-MEG system, the MEG signals are undoubtedly caused by photic blocking and similar with the results measured by SQUID magnetometer.
COMPARISON WITH EXISTING METHODS
Due to the dependency of current commercial whole-cortex SQUID-MEG system on the liquid helium, the separation from the liquid helium space to the human head is usually at least a few centimeters. The wearable OPM-MEG system, however, can significantly improve the detection efficiency since its sensors can be mounted close to scalp, normally less than 1 cm.
CONCLUSIONS
OPM-MEG system successfully detects alpha rhythm blocked by light stimulation and works well in the home-made magnetically shielded environment. OPM-MEG system shows a substitute for the traditional MEG system.
背景
在大多数非侵入性成像技术中，脑磁图（MEG）具有高时间和空间分辨率，并且在确定源活动位置方面具有良好的空间准确性。最近开发的光泵磁力仪（OPM）技术的灵敏度与商业MEG系统中使用的超导量子干涉装置（SQUID）相当。
新方法
双通道OPM-MEG系统通过可穿戴的全皮层3D打印头盔，在磁屏蔽环境中检测人类颅骨枕部区域的α节律光阻断。
结果
OPM-MEG系统能够检测到α节律，MEG信号无疑是由光阻断引起的，并且与SQUID磁力仪测量的结果相似。
与现有方法的比较
由于当前商业全皮层SQUID-MEG系统依赖于液氦，从液氦空间到人头的距离通常至少有几厘米。然而，可穿戴的OPM-MEG系统可以显著提高检测效率，因为其传感器可以安装在靠近头皮的位置，通常小于1厘米。
结论
OPM-MEG系统成功检测到光刺激阻断的α节律，并在自制的磁屏蔽环境中运行良好。OPM-MEG系统显示出可替代传统MEG系统。
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