Schweyer Kerstin, Fatke Bastian, Kreiser Kornelia, Rabe Christian, Seifert Christian, Ikenberg Benno
Technical University of Munich, School of Medicine, Klinikum rechts der Isar, Department of Neurology, München, Germany.
Technical University of Munich, School of Medicine, Klinikum rechts der Isar, Department of Psychiatry and Psychotherapy, München, Germany.
Case Rep Psychiatry. 2020 Aug 31;2020:2398721. doi: 10.1155/2020/2398721. eCollection 2020.
Olanzapine is a second-generation antipsychotic drug which is generally considered safe with well therapeutic antipsychotic effects. We describe a patient suffering from bilateral intracerebral hemorrhage after severe olanzapine intoxication without underlying thrombocytopenia, arterial hypertension, or vascular malformation as cause of intracerebral hemorrhage. This raises the possibility of a direct side effect of high-dose olanzapine intake. So far, intracranial hemorrhage after olanzapine intoxication in such constellation has not been reported before. Given the high number of its prescription rates, our finding of intracranial hemorrhage after olanzapine intoxication is of high clinical relevance.
奥氮平是一种第二代抗精神病药物，通常被认为是安全的，具有良好的抗精神病治疗效果。我们描述了一名患者，在严重奥氮平中毒后发生双侧脑出血，且不存在潜在的血小板减少、动脉高血压或血管畸形作为脑出血的病因。这增加了高剂量服用奥氮平产生直接副作用的可能性。迄今为止，在这种情况下奥氮平中毒后发生颅内出血的情况此前尚未见报道。鉴于其高处方率，我们关于奥氮平中毒后颅内出血的发现具有高度临床相关性。
