中国患者内皮穿透性角膜移植术移植物存活情况的5年分析
A 5-year analysis of endothelial penetrating keratoplasty graft survival in Chinese patients.
作者信息
Li Anita Lai Wah, Kwok Rachel Pui Wai, Kam Ka Wai, Young Alvin Lerrmann
机构信息
Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital & Alice Ho Miu Ling Nethersole Hospital, New Territories East Cluster, Hospital Authority, the Chinese University of Hong Kong, Hong Kong SAR, China.
出版信息
Int J Ophthalmol. 2020 Sep 18;13(9):1374-1377. doi: 10.18240/ijo.2020.09.06. eCollection 2020.
AIM
To determine if there is any difference in long term graft survival between Descemet's stripping endothelial keratoplasty (DSEK) and penetrating keratoplasty (PK).
METHODS
A retrospective 5-year cases analysis of bullous keratopathy secondary to Fuchs' endothelial dystrophy or pseudophakic bullous keratopathy, receiving either DSEK or PK. A total of 42 DSEK cases and 25 PK cases were included in the analysis.
RESULTS
In the 5-year analysis, graft survival rates were very similar in the two groups (DSEK 77.1% PK 76.0%, =0.918, 95%CI: -6.3 to 33.4). Sub-analyses at 1y (DSEK 81% PK 95%, =0.085, 95%CI: -29 to 3.6) and 2y (DSEK 81% PK 88%, =0.381, 95%CI: -25.9 to 11.8) show a trend towards lower survival rates of DSEK PK, but the results were not statistically significant.
CONCLUSION
Long term 5-year graft survival is similar between the DSEK and PK methods of corneal transplant in Chinese patients with bullous keratopathy.
目的
确定Descemet膜剥脱内皮角膜移植术（DSEK）和穿透性角膜移植术（PK）在长期移植物存活方面是否存在差异。
方法
对因Fuchs内皮营养不良或人工晶状体性大疱性角膜病变继发的大疱性角膜病变接受DSEK或PK治疗的患者进行回顾性5年病例分析。分析共纳入42例DSEK病例和25例PK病例。
结果
在5年分析中，两组的移植物存活率非常相似（DSEK为77.1%，PK为76.0%，P = 0.918，95%CI：-6.3至33.4）。1年时的亚分析（DSEK为81%，PK为95%，P = 0.085，95%CI：-29至3.6）和2年时的亚分析（DSEK为81%，PK为88%，P = 0.381，95%CI：-25.9至11.8）显示DSEK的存活率有低于PK的趋势，但结果无统计学意义。
结论
在中国大疱性角膜病变患者中，DSEK和PK两种角膜移植方法的5年长期移植物存活率相似。
Zotero 插件