Park Ji Sook, Jeong Seul-Ah, Cho Jae Young, Seo Ji-Hyun, Lim Jae Young, Woo Hyang Ok, Youn Hee-Shang, Park Chan-Hoo
Department of Pediatrics, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju, Korea.
Institute of Health Sciences, Gyeongsang National University, Jinju, Korea.
Pediatr Gastroenterol Hepatol Nutr. 2020 Sep;23(5):472-483. doi: 10.5223/pghn.2020.23.5.472. Epub 2020 Aug 27.
Sodium is an essential nutritional electrolyte that affects growth. A low serum sodium concentration in healthy premature infants beyond 2 weeks of life is called late-onset hyponatremia (LOH). Here, we investigated the association between LOH severity and growth outcomes in premature infants.
Medical records of premature infants born at ≤32 weeks of gestation were reviewed. LOH was defined as a serum sodium level <135 mEq/L regardless of sodium replacement after 14 days of life. Cases were divided into two groups, <130 mEq/L (severe) and ≥130 mEq/L (mild). Characteristics and growth parameters were compared between the two groups.
A total of 102 premature infants with LOH were included. Gestational age ([GA] 27.7 vs. 29.5 weeks, <0.001) and birth weight (1.04 vs. 1.34 kg, <0.001) were significantly lower in the severe group. GA was a risk factor of severe LOH (odds ratio [OR], 1.328, =0.022), and severe LOH affected the development of bronchopulmonary dysplasia (OR, 2.950, =0.039) and led to a poor developmental outcome (OR, 9.339, =0.049). Growth parameters at birth were lower in the severe group, and a lower GA and sepsis negatively affected changes in growth for 3 years after adjustment for time. However, severe LOH was not related to growth changes in premature infants.
Severe LOH influenced the development of bronchopulmonary dysplasia and developmental outcomes. However, LOH severity did not affect the growth of premature infants beyond the neonatal period.
钠是一种影响生长的必需营养电解质。健康早产儿出生2周后血清钠浓度低被称为迟发性低钠血症（LOH）。在此，我们研究了早产儿LOH严重程度与生长结局之间的关联。
回顾了孕周≤32周的早产儿的病历。LOH定义为出生14天后血清钠水平<135 mEq/L，无论是否进行钠替代治疗。病例分为两组，<130 mEq/L（重度）和≥130 mEq/L（轻度）。比较两组的特征和生长参数。
共纳入102例患有LOH的早产儿。重度组的胎龄（[GA]27.7周对29.5周，<0.001）和出生体重（1.04 kg对1.34 kg，<0.001）显著更低。GA是重度LOH的一个危险因素（比值比[OR]，1.328，=0.022），且重度LOH影响支气管肺发育不良的发生（OR，2.950，=0.039）并导致发育结局不良（OR，9.339，=0.049）。重度组出生时的生长参数更低，且在对时间进行校正后，较低的GA和败血症对3年的生长变化产生负面影响。然而，重度LOH与早产儿的生长变化无关。
重度LOH影响支气管肺发育不良的发生和发育结局。然而，LOH严重程度不影响早产儿新生儿期后的生长。
