Marcu Radu Dragos, Mischianu Dan Liviu Dorel, Iorga Lucian, Diaconu Camelia Cristina, Surcel Mihaela, Munteanu Adriana Narcisa, Constantin Carolina, Isvoranu Gheorghita, Bratu Ovidiu Gabriel
Clinic of Urology, University Emergency Central Military Hospital, 134 Calea Plevnei, 010825 Bucharest, Romania].
University of Medicine and Pharmacy, 37 Dionisie Lupu Street, 020021 Bucharest, Romania.
J Immunol Res. 2020 Sep 1;2020:3791934. doi: 10.1155/2020/3791934. eCollection 2020.
Pelvic organ prolapse is a frequent health problem in women, encountered worldwide, its physiopathology being still incompletely understood. The integrity of the pelvic-supportive structures is a key element that prevents the prolapse of the pelvic organs. Numerous researchers have underlined the role of connective tissue molecular changes in the pathogenesis of pelvic organ prolapse and have raised the attention upon oxidative stress as an important element involved in its appearance. The advancements made over the years in terms of molecular biology have allowed researchers to investigate how the constituent elements of the pelvic-supportive structures react in conditions of oxidative stress. The purpose of this paper is to underline the importance of oxidative stress in the pathogenesis of pelvic organ prolapse, as well as to highlight the main oxidative stress molecular changes that appear at the level of the pelvic-supportive structures. Sustained mechanical stress is proven to be a key factor in the appearance of pelvic organ prolapse, correlating with increased levels of free radicals production and mitochondrial-induced fibroblasts apoptosis, the rate of cellular apoptosis depending on the intensity of the mechanical stress, and the period of time the mechanical stress is applied. Oxidative stress hinders normal cellular signaling pathways, as well as different important cellular components like proteins, lipids, and cellular DNA, therefore significantly interfering with the process of collagen and elastin synthesis.
盆腔器官脱垂是一种在全球范围内女性中常见的健康问题，其病理生理学仍未被完全理解。盆腔支持结构的完整性是防止盆腔器官脱垂的关键因素。众多研究人员强调了结缔组织分子变化在盆腔器官脱垂发病机制中的作用，并将氧化应激作为其出现的一个重要因素引起了关注。多年来分子生物学方面的进展使研究人员能够研究盆腔支持结构的组成元素在氧化应激条件下如何反应。本文的目的是强调氧化应激在盆腔器官脱垂发病机制中的重要性，并突出在盆腔支持结构水平上出现的主要氧化应激分子变化。持续的机械应力被证明是盆腔器官脱垂出现的关键因素，与自由基产生水平增加和线粒体诱导的成纤维细胞凋亡相关，细胞凋亡率取决于机械应力的强度以及施加机械应力的时间段。氧化应激阻碍正常的细胞信号通路以及蛋白质、脂质和细胞DNA等不同重要细胞成分，因此显著干扰胶原蛋白和弹性蛋白的合成过程。
