Department of Dermatology and Venereology Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia.
Int J Dermatol. 2020 Dec;59(12):1506-1512. doi: 10.1111/ijd.15178. Epub 2020 Sep 21.
Purple variant of passion fruit (Passiflora edulis Sims var. edulis) is a tropical plant commonly used in the beverage industry. The seeds have high content of linoleic acid and piceatannol which has been reported and showed antibacterial, anti-inflammatory, and antioxidant activities. However, there is no report regarding its effect on acne vulgaris.
To determine the efficacy of topical use of Passiflora edulis Sims var. edulis seeds extract on acne vulgaris.
In this open-label uncontrolled trial, 45 subjects with acne vulgaris were given passion fruit purple variant seeds extract 10% cream for 8 weeks. Noninflammatory, inflammatory, and total acne lesions count along with ultraviolet-induced red fluorescence (UVRF) measurement were done at weeks 0, 2, 4, 6, and 8. All reported adverse events were documented, and patient satisfaction rates were determined at week 8. Paired T-test and Wilcoxon test were done with P ≤ 0.05 indicating significance.
There were significant reductions in noninflammatory (80.9%), inflammatory (71.1%), and total (73%) lesion count after 8 weeks of the cream application (P < 0.001). Significant reduction in UVRF spot quantity (36%) and percentage area (45.9%) were found at week 8 (P < 0.001). Only 2.2% of subjects experienced an adverse event of mild and transient peeling. Most of the subjects (77.8%) noticed significant improvement in their acne vulgaris and expressed good satisfaction rate.
Topical use of passion fruit purple variant seeds extract improves acne vulgaris with reduction in lesion counts and UVRF, minimal adverse events, and good satisfaction rate. Additional prospective studies are required.
西番莲（Passiflora edulis Sims var. edulis）的紫色品种是一种常用于饮料行业的热带植物。其种子含有丰富的亚油酸和白皮杉醇，具有抗菌、抗炎和抗氧化活性。然而，目前尚无关于其对寻常痤疮影响的报道。
评估西番莲紫色品种种子提取物局部应用于寻常痤疮的疗效。
在这项开放性、非对照临床试验中，45 例寻常痤疮患者使用 10%西番莲紫色品种种子提取物乳膏，治疗 8 周。在第 0、2、4、6 和 8 周时，分别记录非炎性、炎性和总痤疮皮损计数，以及紫外线诱导的红色荧光（UVRF）测量值。记录所有报告的不良事件，并在第 8 周时评估患者的满意度。P≤0.05 表示差异具有统计学意义，采用配对 T 检验和 Wilcoxon 检验进行分析。
使用乳膏治疗 8 周后，非炎性（80.9%）、炎性（71.1%）和总（73%）皮损计数均显著减少（P＜0.001）。在第 8 周时，UVRF 光斑数量（36%）和百分比面积（45.9%）也显著减少（P＜0.001）。仅有 2.2%的受试者出现轻度且短暂的脱皮不良事件。大多数受试者（77.8%）认为痤疮明显改善，满意度较高。
局部使用西番莲紫色品种种子提取物可改善寻常痤疮，减少皮损计数和 UVRF，不良事件轻微，患者满意度高。需要进一步开展前瞻性研究。
