First Affiliated Hospital of Hunan Normal University, Hunan Provincial People's Hospital, Changsha, China.
Key Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, Hunan Normal University, Changsha, China.
Lipids. 2021 Jan;56(1):93-100. doi: 10.1002/lipd.12279. Epub 2020 Sep 21.
Previous studies have explored the relationship between homocystein (Hcy) and lipid profiles. However, the results from these studies have been inconsistent. The current study investigated the correlation between Hcy and lipid profiles in Chinese community-based population. The participants were composed of 4012 Chinese people aged 30-92 years old, who were recruited from rural and urban communities in the Hunan Province. Non-parametric test and logistic regression were used to examine the distribution of Hcy and lipid profiles (triglyceride [TG], total cholesterol [TC], low-density lipoprotein cholesterol [LDL-C], high-density lipoprotein cholesterol [HDL-C]) and the relationship between them. The median age of subjects was 54.50 years old, and 40.98% were male. Median Hcy was 13.20 μmol/L, and 35.39% had hyperhomocysteinemia (HHcy). Median TG was 1.51 mmol/L, TC was 4.77 mmol/L, LDL-C was 2.62 mmol/L, and HDL-C was 1.27 mmol/L. In multivariable logistic regression analysis, HHcy was associated with high levels of TG (OR = 2.240, p < 0.001; OR = 2.539, p < 0.001), TC (OR = 2.237, p < 0.001; OR = 2.202, p < 0.001), and LDL-C (OR = 1.413, p = 0.010; OR = 1.617, p < 0.001) in the different sexes population and low level of HDL-C in females (OR = 1.326, p = 0.023) after adjusting for confounders. HHcy was independently associated with an increasing risk of low HDL-C among females. The regression analysis showed that HHcy was also associated with hypertriglyceridemia, hypercholesterolemia, and high level of LDL-C in males and females from Chinese community-based population, which provides a basis for the treatment and prevention of abnormal lipid metabolism.
先前的研究探讨了同型半胱氨酸（Hcy）与血脂谱之间的关系。然而，这些研究的结果并不一致。本研究旨在探究中国社区人群中 Hcy 与血脂谱之间的相关性。研究对象由来自湖南省农村和城市社区的 4012 名 30-92 岁的中国人组成。采用非参数检验和 logistic 回归分析方法来检测 Hcy 与血脂谱（甘油三酯 [TG]、总胆固醇 [TC]、低密度脂蛋白胆固醇 [LDL-C]、高密度脂蛋白胆固醇 [HDL-C]）的分布情况以及它们之间的关系。研究对象的中位年龄为 54.50 岁，其中 40.98%为男性。中位 Hcy 为 13.20 μmol/L，35.39%的人存在高同型半胱氨酸血症（HHcy）。中位 TG 为 1.51mmol/L，TC 为 4.77mmol/L，LDL-C 为 2.62mmol/L，HDL-C 为 1.27mmol/L。多变量 logistic 回归分析显示，HHcy 与男性 TG 水平升高（OR = 2.240，p < 0.001；OR = 2.539，p < 0.001）、TC 水平升高（OR = 2.237，p < 0.001；OR = 2.202，p < 0.001）、LDL-C 水平升高（OR = 1.413，p = 0.010；OR = 1.617，p < 0.001）有关，且与女性 HDL-C 水平降低（OR = 1.326，p = 0.023）有关。在调整了混杂因素后，HHcy 与女性低 HDL-C 血症的发生风险增加独立相关。回归分析显示，HHcy 与男性和女性的高甘油三酯血症、高胆固醇血症和 LDL-C 水平升高也有关，为异常血脂代谢的治疗和预防提供了依据。
