Qin Yuan-Yuan, Wang Peng, Qin Jin-Qiu, Wei Ai-Qiu, Huang Ping, Lai Zhan-Feng, Lin Fa-Quan
Department of Clinical Laboratory, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China.
Department of Medical Center, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China.
J Clin Lab Anal. 2018 Jan;32(1). doi: 10.1002/jcla.22178. Epub 2017 Apr 10.
Studies on homocysteine (Hcy) have mainly focused on the correlation between the homocysteine concentration and disease development. Few epidemiological investigations have been performed. This study was conducted to investigate the prevalence of hyperhomocysteinemia (HHcy) during routine physical examination in Guangxi Province, China and the correlation of serum Hcy with gender, age, serum uric acid (UA), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and blood glucose (GLU) to provide evidence for preventing and treating HHcy.
Data of 8043 patients who underwent physical examinations at the First Affiliated Hospital of Guangxi Medical University, China from 2015 to 2016 were collected. These data included gender, age, and the serum Hcy, UA, GLU, TC, TG, HDL-C, and LDL-C concentrations.
The overall prevalence of HHcy was 50.8% (52.3% in males, 48.1% in females). Age, UA, TC, TG, and LDL-C were significantly higher and HDL-C was significantly lower in patients with than without HHcy, regardless of gender (all P<.05). The Hcy level was positively correlated with UA, TC, TG, and LDL-C but negatively correlated with HDL-C. Gender, age, UA, TC, and TG were independent risk factors for HHcy.
The prevalence of HHcy was very high during routine physical examination in Guangxi Province, China. HHcy was related to gender, age, high concentrations of UA, TC, TG, and LDL-C; and low concentrations of HDL-C. Strengthening early intervention of HHcy can reduce the risk of cardiovascular disease.
关于同型半胱氨酸（Hcy）的研究主要集中在同型半胱氨酸浓度与疾病发展之间的相关性。很少有流行病学调查。本研究旨在调查中国广西地区常规体检期间高同型半胱氨酸血症（HHcy）的患病率，以及血清Hcy与性别、年龄、血清尿酸（UA）、总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）和血糖（GLU）的相关性，为HHcy的防治提供依据。
收集了2015年至2016年在中国广西医科大学第一附属医院接受体检的8043例患者的数据。这些数据包括性别、年龄以及血清Hcy、UA、GLU、TC、TG、HDL-C和LDL-C浓度。
HHcy的总体患病率为50.8%（男性为52.3%，女性为48.1%）。无论性别如何，HHcy患者的年龄、UA、TC、TG和LDL-C均显著高于非HHcy患者，而HDL-C显著低于非HHcy患者（所有P<0.05）。Hcy水平与UA、TC、TG和LDL-C呈正相关，但与HDL-C呈负相关。性别、年龄、UA、TC和TG是HHcy的独立危险因素。
在中国广西地区常规体检期间，HHcy的患病率非常高。HHcy与性别、年龄、高浓度的UA、TC、TG和LDL-C以及低浓度的HDL-C有关。加强对HHcy的早期干预可降低心血管疾病风险。
