• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

N-methyl-N'-nitro-N-nitrosoguanidine-induced resistance to ionizing radiation.

作者信息

Morse M L, Smith D S

出版信息

Mol Gen Genet. 1987 Feb;206(2):220-5. doi: 10.1007/BF00333577.

DOI:10.1007/BF00333577
PMID:3295481
Abstract

N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) pretreatments increase the resistance of Escherichia coli to gamma-radiation. The increased resistance is dependent on functional polA, recA, recB, recC, and lexA genes and is partly dependent on recN. The MNNG-induced resistance is additive to resistance induced by pretreatment with gamma-radiation but not by increases induced by hydrogen peroxide. The MNNG-induced resistance occurs in adaptive response mutants and at pretreatment levels of MNNG that do not activate cells to reactivate UV-inactivated lambda phage. The MNNG-induced resistance appears to be distinct from other inductions to gamma-radiation resistance.

摘要

相似文献

1
N-methyl-N'-nitro-N-nitrosoguanidine-induced resistance to ionizing radiation.
Mol Gen Genet. 1987 Feb;206(2):220-5. doi: 10.1007/BF00333577.
2
Induction of prophage lambda in Escherichia coli recA- strain by N-methyl-N'-nitro-N-nitrosoguanidine.N-甲基-N'-硝基-N-亚硝基胍诱导大肠杆菌recA-菌株中的λ原噬菌体
Mutat Res. 1983 Jan;107(1):33-40. doi: 10.1016/0027-5107(83)90076-3.
3
Involvement of mismatch repair proteins in adaptive responses induced by N-methyl-N'-nitro-N-nitrosoguanidine against γ-induced genotoxicity in human cells.错配修复蛋白在 N-甲基-N'-硝基-N-亚硝胍诱导的人细胞对 γ 诱导遗传毒性的适应性反应中的作用。
Mutat Res. 2011 Aug 1;713(1-2):56-63. doi: 10.1016/j.mrfmmm.2011.05.014. Epub 2011 Jun 15.
4
Characterization of an Escherichia coli mutant (radB101) sensitive to gamma and uv radiation, and methyl methanesulfonate.对γ射线、紫外线辐射及甲磺酸甲酯敏感的大肠杆菌突变体（radB101）的特性分析
Radiat Res. 1983 Mar;93(3):461-78.
5
Role of ruvAB genes in UV- and gamma-radiation and chemical mutagenesis in Escherichia coli.ruvAB基因在大肠杆菌紫外线、γ射线及化学诱变中的作用
Mutat Res. 1989 Nov;215(1):115-29. doi: 10.1016/0027-5107(89)90224-8.
6
Hydrogen peroxide induces protection against N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) effects in Escherichia coli.过氧化氢可诱导大肠杆菌对N-甲基-N'-硝基-N-亚硝基胍（MNNG）的作用产生抗性。
Mutat Res. 1997 Mar 12;383(2):137-42. doi: 10.1016/s0921-8777(96)00053-5.
7
Antimutagenic action of mammalian placental extracts on mutations induced in Escherichia coli by UV radiation, gamma-rays and N-methyl-N'-nitro-N-nitrosoguanidine.
Mutat Res. 1982 Aug;95(2-3):457-74. doi: 10.1016/0027-5107(82)90278-0.
8
U.v.-induced and N-methyl-N'-nitro-N-nitrosoguanidine-induced mutagenesis in Bacillus thuringiensis.紫外线诱导和N-甲基-N'-硝基-N-亚硝基胍诱导苏云金芽孢杆菌的诱变作用。
Mutagenesis. 1987 Mar;2(2):107-9. doi: 10.1093/mutage/2.2.107.
9
[Protective action of colicinogenic factor Ib-P9 on Escherichia coli cells defective in known repair functions after ultraviolet irradiation].[产大肠杆菌素因子Ib-P9对紫外线照射后已知修复功能存在缺陷的大肠杆菌细胞的保护作用]
Genetika. 1979 Sep;15(9):1578-87.
10
Misrepair mutagenesis in Myxococcus xanthus: induction of rifampicin-resistant mutants by N-methyl-N'-nitro-N-nitrosoguanidine and ultraviolet-irradiation.黄色黏球菌中的错配诱变：N-甲基-N'-硝基-N-亚硝基胍和紫外线照射诱导利福平抗性突变体
Mol Gen Genet. 1981;182(2):304-9. doi: 10.1007/BF00269675.

引用本文的文献

1
Low doses of radiation are protective in vitro and in vivo: evolutionary origins.低剂量辐射具有保护作用：体外和体内的进化起源。
Dose Response. 2006 Aug 19;4(2):75-90. doi: 10.2203/dose-response.04-002.Mitchel.

本文引用的文献

1
Adaptation to alkylation resistance involves the induction of a DNA glycosylase.对烷化抗性的适应涉及一种DNA糖基化酶的诱导。
Nature. 1982 Apr 22;296(5859):773-5. doi: 10.1038/296773a0.
2
Induction of a DNA glycosylase for N-methylated purines is part of the adaptive response to alkylating agents.诱导一种针对N-甲基化嘌呤的DNA糖基化酶是对烷化剂适应性反应的一部分。
Nature. 1982 Apr 22;296(5859):770-3. doi: 10.1038/296770a0.
3
Induced radioresistance: an aspect of induced repair.诱导抗性：诱导修复的一个方面。
Mol Gen Genet. 1981;184(3):421-9. doi: 10.1007/BF00352516.
4
Inducibility of a gene product required for UV and chemical mutagenesis in Escherichia coli.大肠杆菌中紫外线和化学诱变所需基因产物的可诱导性。
Proc Natl Acad Sci U S A. 1981 Sep;78(9):5749-53. doi: 10.1073/pnas.78.9.5749.
5
Repair of DNA double-strand breaks in Escherichia coli cells requires synthesis of proteins that can be induced by UV light.大肠杆菌细胞中DNA双链断裂的修复需要合成可被紫外线诱导的蛋白质。
Proc Natl Acad Sci U S A. 1981 Jun;78(6):3450-3. doi: 10.1073/pnas.78.6.3450.
6
Isolation of mutants of Escherichia coli with increased resistance to alkylating agents: mutants deficient in thiols and mutants constitutive for the adaptive response.具有增强的对烷化剂抗性的大肠杆菌突变体的分离：硫醇缺陷型突变体和适应性反应组成型突变体。
Mol Gen Genet. 1980;180(1):85-90. doi: 10.1007/BF00267355.
7
Repair of alkylated DNA in Escherichia coli. Methyl group transfer from O6-methylguanine to a protein cysteine residue.大肠杆菌中烷基化DNA的修复。甲基从O6-甲基鸟嘌呤转移至蛋白质半胱氨酸残基。
J Biol Chem. 1980 Nov 25;255(22):10569-71.
8
SOS chromotest, a direct assay of induction of an SOS function in Escherichia coli K-12 to measure genotoxicity.SOS 显色试验，一种直接检测大肠杆菌 K-12 中 SOS 功能诱导以测量遗传毒性的方法。
Proc Natl Acad Sci U S A. 1982 Oct;79(19):5971-5. doi: 10.1073/pnas.79.19.5971.
9
Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli.大肠杆菌中的诱变作用及对脱氧核糖核酸损伤的诱导反应
Microbiol Rev. 1984 Mar;48(1):60-93. doi: 10.1128/mr.48.1.60-93.1984.
10
Inducible repair of phosphotriesters in Escherichia coli.大肠杆菌中磷酸三酯的可诱导修复
Proc Natl Acad Sci U S A. 1983 Dec;80(24):7380-4. doi: 10.1073/pnas.80.24.7380.