Bergerot Cristiane Decat, Battle Dena, Philip Errol J, Bergerot Paulo Gustavo, Msaouel Pavlos, Smith Allan 'Ben', Bamgboje Adeola Esther, Shuch Brian, Derweesh Ithaar H, Jonasch Eric, Stern Adam P, Pal Sumanta K, Staehler Michael
Department of Medical Oncology and Experimental Therapeutics, City of Hope Comprehensive Cancer Center, Duarte, CA.
Kidney Cancer Research Alliance, Alexandria, VA.
JCO Oncol Pract. 2020 Nov;16(11):e1264-e1271. doi: 10.1200/OP.20.00105. Epub 2020 Sep 18.
Patients with cancer commonly report distress and fear of cancer recurrence (FCR) impacting quality of life and clinical outcomes. This study aims to test the association between emotional well-being and clinical characteristics of survivors with localized renal cell carcinoma (RCC).
Survivors with localized RCC were invited to participate in this study through social media by the Kidney Cancer Research Alliance. Participants self-reported clinical characteristics, distress (Distress Thermometer), and FCR (Fear of Cancer Recurrence-7). Ordinal regression was used to test the association between emotional well-being and patient characteristics.
A total of 412 survivors were included in this analysis. Participants were mostly female (79.4%) and well educated (58.3%), with a median age of 54 years (range, 30-80 years) and median time since diagnosis of 17.5 months. More than one half were diagnosed with stage I disease (56.1%). Most patients (62.3%) had a clear understanding of their diagnosis. A high prevalence of moderate to severe distress (67.0%) and FCR (54.9%) was reported across all survivors of RCC. Higher FCR was associated with female gender, younger age, and lack of understanding of their diagnosis ( = .001), whereas more recent diagnosis was associated with higher distress levels ( = .01).
Our findings suggest that FCR is a common problem that is persistent after therapy and that certain individuals, including female and younger patients, may be at particular risk of experiencing clinically relevant FCR.
癌症患者常报告有痛苦以及对癌症复发的恐惧（FCR），这会影响生活质量和临床结局。本研究旨在检验局限性肾细胞癌（RCC）幸存者的情绪健康与临床特征之间的关联。
肾癌研究联盟通过社交媒体邀请局限性RCC幸存者参与本研究。参与者自行报告临床特征、痛苦程度（痛苦温度计）和FCR（癌症复发恐惧量表-7）。采用有序回归分析来检验情绪健康与患者特征之间的关联。
本分析共纳入412名幸存者。参与者大多为女性（79.4%），且受教育程度较高（58.3%），中位年龄为54岁（范围30 - 80岁），自诊断以来的中位时间为17.5个月。超过一半的患者被诊断为I期疾病（56.1%）。大多数患者（62.3%）对自己的诊断有清晰的了解。在所有RCC幸存者中，报告有中度至重度痛苦（67.0%）和FCR（54.9%）的比例很高。较高的FCR与女性、年轻以及对自身诊断缺乏了解有关（P = .001），而更近的诊断与更高的痛苦水平有关（P = .01）。
我们的研究结果表明，FCR是一个常见问题，在治疗后仍然存在，并且某些个体，包括女性和年轻患者，可能特别容易出现具有临床意义的FCR。
