Biological Sciences Department, University of Memphis, Memphis, Tennessee, USA.
Jeneil Biotech Inc, Saukville, Wisconsin, USA.
J Environ Sci Health C Toxicol Carcinog. 2020;38(3):245-268. doi: 10.1080/26896583.2020.1809286.
The large-scale applications of Triclosan in industrial and household products have created many health and environmental concerns. Despite the fears of its drug-resistance and other issues, Triclosan is still an effective drug against many infectious organisms. Knowing the cross-interactions of Triclosan with different antibiotics, bacteria, and humans can provide much-needed information for the risk assessment of this drug. We review the current understanding of the antimicrobial mechanisms of Triclosan, how microbes become resistant to Triclosan, and the synergistic and antagonistic effects of Triclosan with different antibiotics. Current literature on the clinical applications of Triclosan and its effect on fetus/child development are also summarized.
三氯生在工业和家用产品中的大规模应用引发了诸多健康和环境方面的担忧。尽管人们担心其会产生抗药性和其他问题，但三氯生仍然是对抗许多传染性生物体的有效药物。了解三氯生与不同抗生素、细菌和人类之间的相互作用，可以为这种药物的风险评估提供急需的信息。我们综述了目前对三氯生抗菌机制的认识、微生物对三氯生产生抗药性的方式，以及三氯生与不同抗生素之间的协同和拮抗作用。此外，还总结了目前关于三氯生在临床应用及其对胎儿/儿童发育影响的文献。
