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经颅直流电刺激治疗 ADHD 大鼠模型的疗效。

Therapeutic effects of anodal transcranial direct current stimulation in a rat model of ADHD.

机构信息

Department of Korean Medical Science, School of Korean Medicine, Pusan National University, Yangsan, Republic of Korea.

Graduate Training Program of Korean Medicine for Healthy Aging, Pusan National University, Yangsan, Republic of Korea.

出版信息

Elife. 2020 Sep 21;9:e56359. doi: 10.7554/eLife.56359.

DOI:10.7554/eLife.56359
PMID:32955434
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7535928/
Abstract

Most therapeutic candidates for treating attention-deficit hyperactivity disorder (ADHD) have focused on modulating the dopaminergic neurotransmission system with neurotrophic factors. Regulation of this system by transcranial direct current stimulation (tDCS) could contribute to the recovery of cognitive symptoms observed in patients with ADHD. Here, male spontaneously hypertensive rats (SHR) were subjected to consecutive high-definition tDCS (HD-tDCS) (20 min, 50 μA, current density 63.7 A/m, charge density 76.4 kC/m) over the prefrontal cortex. This treatment alleviated cognitive deficits, with an increase in tyrosine hydroxylase and vesicular monoamine transporter two and significantly decreased plasma membrane reuptake transporter (DAT). HD-tDCS application increased the expression of several neurotrophic factors, particularly brain-derived neurotrophic factor (BDNF), and activated hippocampal neurogenesis. Our results suggest that anodal HD-tDCS over the prefrontal cortex may ameliorate cognitive dysfunction via regulation of DAT and BDNF in the mesocorticolimbic dopaminergic pathways, and therefore represents a potential adjuvant therapy for ADHD.

摘要

大多数治疗注意力缺陷多动障碍（ADHD）的候选药物都集中在调节神经营养因子的多巴胺能神经传递系统。经颅直流电刺激（tDCS）对该系统的调节可能有助于恢复 ADHD 患者观察到的认知症状。在这里，雄性自发性高血压大鼠（SHR）接受了连续的高清晰度 tDCS（HD-tDCS）（20 分钟，50μA，电流密度 63.7A/m，电荷密度 76.4kC/m）在前额叶皮层上。这种治疗减轻了认知障碍，酪氨酸羟化酶和囊泡单胺转运体 2 增加，而细胞膜再摄取转运体（DAT）显著减少。HD-tDCS 应用增加了几种神经营养因子的表达，特别是脑源性神经营养因子（BDNF），并激活了海马神经发生。我们的结果表明，在前额叶皮层进行阳极 HD-tDCS 可能通过调节中皮质边缘多巴胺能通路中的 DAT 和 BDNF 来改善认知功能障碍，因此代表了 ADHD 的一种潜在辅助治疗方法。

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