Gvozdjakova A, Kucharska J, Sumbalova Z, Rausova Z, Chladekova A, Komlosi M, Szamosova M, Mojto V
Bratisl Lek Listy. 2020;121(10):693-699. doi: 10.4149/BLL_2020_113.
The mortality of patients with chronic kidney diseases (CKD) increases with the decrease in glomerular filtration rate (eGFR). In the progress of CKD that is closely linked to non-communicable diseases (NCDs), the role of coenzyme Q10 (CoQ10) is not fully evaluated. We aimed to evaluate the importance of CoQ10, CoQ10/cholesterol ratio, and oxidative stress in the progress of CKD.
The control group was constituted of 19 healthy subjects who volunteered to enrol in the study, CKD group consisted of 58 patients with CKD, of whom 54 had CKD combined with hypertension, 22 had CKD combined with hypertension and diabetes type 2 , and 18 had CKD combined with hypertension and statin therapy. We observed age, BMI, creatinine, uric acid, eGFR, hemoglobin, CRP, glucose, lipids fraction, and liver enzymes. Coenzyme Q10-TOTAL (ubiquinol+ubiquinone) in platelets and plasma were determined using HPLC method with UV detection. Indexed of CoQ10/lipid fractions were evaluated. Oxidative stress was determined as thiobarbituric acid‑reactive substances (TBARS).
With increased stages of CKD, eGFR and CoQ10 as well as its ratio to lipids were significantly reduced while TBARS increased.
We assume that lower endogenous CoQ10 level may be one of the reasons of kidney dysfunction. CoQ10/lipids ratio and increase in oxidative stress can predict the progression of CKD in patients with arterial hypertension, diabetes mellitus and dyslipidemia (Tab. 2, Fig. 4, Ref. 49).
慢性肾脏病（CKD）患者的死亡率随肾小球滤过率（eGFR）的降低而增加。在与非传染性疾病（NCDs）密切相关的CKD进展过程中，辅酶Q10（CoQ10）的作用尚未得到充分评估。我们旨在评估CoQ10、CoQ10/胆固醇比值和氧化应激在CKD进展中的重要性。
对照组由19名自愿参加本研究的健康受试者组成，CKD组由58例CKD患者组成，其中54例合并高血压，22例合并高血压和2型糖尿病，18例合并高血压并接受他汀类药物治疗。我们观察了年龄、体重指数、肌酐、尿酸、eGFR、血红蛋白、CRP、血糖、血脂组分和肝酶。采用高效液相色谱法（HPLC）结合紫外检测法测定血小板和血浆中的辅酶Q10总量（泛醇+泛醌）。评估CoQ10/脂质组分指标。氧化应激以硫代巴比妥酸反应性物质（TBARS）来确定。
随着CKD分期增加，eGFR、CoQ10及其与脂质的比值显著降低，而TBARS升高。
我们认为内源性CoQ10水平降低可能是肾功能不全的原因之一。CoQ10/脂质比值和氧化应激增加可预测动脉高血压、糖尿病和血脂异常患者的CKD进展（表2，图4，参考文献49）。
