蛋白磷酸酶 1 在肿瘤发生中的作用：是否值得进一步研究？

Protein phosphatase 1 in tumorigenesis: is it worth a closer look?

机构信息

Laboratory of Signal Transduction, Department of Medical Sciences, Institute of Biomedicine - iBiMED, University of Aveiro, 3810-193, Aveiro, Portugal; Cancer Biology and Epigenetics Group, IPO Porto Research Center (CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto), 4200-072, Porto, Portugal.

Cancer Biology and Epigenetics Group, IPO Porto Research Center (CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto), 4200-072, Porto, Portugal; Department of Pathology and Molecular Immunology, Institute of Biomedical Sciences Abel Salazar, University of Porto (ICBAS-UP), 4050-313, Porto, Portugal.

出版信息

Biochim Biophys Acta Rev Cancer. 2020 Dec;1874(2):188433. doi: 10.1016/j.bbcan.2020.188433. Epub 2020 Sep 19.

DOI:10.1016/j.bbcan.2020.188433

PMID:32956763

Abstract

Cancer cells take advantage of signaling cascades to meet their requirements for sustained growth and survival. Cell signaling is tightly controlled by reversible protein phosphorylation mechanisms, which require the counterbalanced action of protein kinases and protein phosphatases. Imbalances on this system are associated with cancer development and progression. Protein phosphatase 1 (PP1) is one of the most relevant protein phosphatases in eukaryotic cells. Despite the widely recognized involvement of PP1 in key biological processes, both in health and disease, its relevance in cancer has been largely neglected. Here, we provide compelling evidence that support major roles for PP1 in tumorigenesis.

摘要

癌细胞利用信号级联反应来满足其持续生长和存活的需求。细胞信号转导受到可逆蛋白磷酸化机制的严格控制，该机制需要蛋白激酶和蛋白磷酸酶的平衡作用。该系统的失衡与癌症的发生和发展有关。蛋白磷酸酶 1（PP1）是真核细胞中最重要的蛋白磷酸酶之一。尽管人们广泛认识到 PP1 在健康和疾病中的关键生物学过程中都有参与，但它在癌症中的相关性在很大程度上被忽视了。在这里，我们提供了令人信服的证据，支持 PP1 在肿瘤发生中的主要作用。