帕金森病补充和替代疗法的疗效与安全性比较：一项贝叶斯网络荟萃分析方案
Comparison of efficacy and safety of complementary and alternative therapies for Parkinson's disease: A Bayesian network meta-analysis protocol.
作者信息
Li Chuancheng, An Hongqiang, Wang Jiahao, Jiang Zhenyuan, Zhang Tianqi, Huo Qing
机构信息
First College of Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan.
Department of Neurology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China.
出版信息
Medicine (Baltimore). 2020 Sep 18;99(38):e22265. doi: 10.1097/MD.0000000000022265.
BACKGROUND
In recent years, the incidence of Parkinson's disease (PD) has been on the rise. However, the existing therapy of PD cannot fundamentally treat the disease. Meanwhile, the complementary and alternative therapies of PD have played a positive role in the treatment of PD. Traditional meta-analysis was only able to compare 2 interventions, while the efficacy and safety of many complementary and alternative therapies were not comparable. Therefore, this study compared the efficacy and safety of different complementary and alternative therapies through network meta-analysis (NMA).
METHODS
A comprehensive search of randomized controlled trials of complementary and alternative therapies for PD, as well as trials currently in progress, will be conducted until August 2020. Literature and data extraction were independently completed by two researchers. Through the meta-analysis of pairwise comparison and Bayesian NMA, all evidences are comprehensively evaluated. Use STATA15.0 and WinBUGS1.4.3 software for data processing and analysis, and use grading of recommendations assessment development and evaluation to classify the quality of evidence in the NMA.
RESULTS
The aim of this study is to obtain a ranking of efficacy and safety of different complementary and alternative therapies for PD.
CONCLUSION
Complementary and alternative therapies for PD have positive significance in improving the symptoms of PD, and can provide evidence support for clinicians and patients.
INPLASY REGISTRATION NUMBER
INPLASY202080079.
背景
近年来，帕金森病（PD）的发病率呈上升趋势。然而，现有的帕金森病治疗方法无法从根本上治愈该疾病。与此同时，帕金森病的补充和替代疗法在其治疗中发挥了积极作用。传统的荟萃分析只能比较两种干预措施，而许多补充和替代疗法的疗效和安全性无法进行比较。因此，本研究通过网状荟萃分析（NMA）比较了不同补充和替代疗法的疗效和安全性。
方法
对帕金森病补充和替代疗法的随机对照试验以及正在进行的试验进行全面检索，直至2020年8月。文献和数据提取由两名研究人员独立完成。通过成对比较的荟萃分析和贝叶斯网状荟萃分析，对所有证据进行综合评估。使用STATA15.0和WinBUGS1.4.3软件进行数据处理和分析，并使用推荐评估、制定与评价分级系统对网状荟萃分析中的证据质量进行分类。
结果
本研究的目的是获得不同帕金森病补充和替代疗法的疗效和安全性排名。
结论
帕金森病的补充和替代疗法对改善帕金森病症状具有积极意义，可为临床医生和患者提供证据支持。
INPLASY注册号：INPLASY202080079。
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