LHRH treatment of hypothalamic amenorrhoea.

Chronic intermittent intravenous administration of 13 micrograms LHRH every 88 minutes for 28 days, was successful in inducing ovulation in two patients with 3a type secondary hypothalamic amenorrhoea. A catheter phlebitis was the only side effect of the treatment and it could be easily prevented by more flexible, thin venous catheters. The minimum laboratory need for monitoring the treatment, and the absence of hyperstimulation of the ovaries suggested the superiority of this substance to hMG for ovulation induction in clomiphene negative patients.