Staub Eveline, Urfer-Maurer Natalie, Lemola Sakari, Risch Lorenz, Evers Katrina S, Welzel Tatjana, Pfister Marc
Department of Neonatology, Royal North Shore Hospital, St Leonards, NSW 2065, Australia.
Department of Neonatology, University of Basel Children's Hospital, 4056 Basel, Switzerland.
Children (Basel). 2020 Sep 17;7(9):141. doi: 10.3390/children7090141.
Preterm infants are at an increased risk of developing hypertension and chronic kidney disease later in life. No recommendations exist for blood pressure (BP) and renal follow up for these patients.
To compare BP and serum and urinary kidney markers between preterm-born adolescents and term-born controls.
BP measurements in 51 preterm-born (≤32 weeks gestational age) and 82 term-born adolescents at the age of 10-15 years were conducted. Stepwise regression analysis explored the association between BP and participant characteristics. Kidney markers measured in the serum and urine were creatinine, neutrophil gelatinase-associated lipocalin (NGAL), and uromodulin. Kidney markers measured in the serum were cystatin C, beta-2 microglobulin, and beta trace protein.
Systolic BP was significantly higher in preterm boys compared with term boys, but not in girls, and low birth weight was associated with higher BP in boys. In the preterm group, maternal hypertension/preeclampsia and adolescent height were associated with higher systolic BP. Serum creatinine and NGAL were significantly higher in the preterm group.
Our study confirms an inverse sex-dependant relationship between birth weight and BP at adolescent age. The higher serum creatinine and NGAL in the preterm group may indicate that premature birth affects kidney function in the long term.
早产儿在日后患高血压和慢性肾病的风险增加。目前尚无针对这些患者的血压（BP）和肾脏随访的建议。
比较早产青少年和足月出生对照者的血压、血清及尿液肾脏标志物。
对51名孕周≤32周的早产青少年和82名10 - 15岁的足月出生青少年进行血压测量。逐步回归分析探讨血压与参与者特征之间的关联。在血清和尿液中测量的肾脏标志物包括肌酐、中性粒细胞明胶酶相关脂质运载蛋白（NGAL）和尿调节蛋白。在血清中测量的肾脏标志物包括胱抑素C、β2微球蛋白和β-微量蛋白。
与足月出生的男孩相比，早产男孩的收缩压显著更高，但女孩中无此差异，且低出生体重与男孩的血压升高有关。在早产组中，母亲高血压/先兆子痫和青少年身高与较高的收缩压有关。早产组的血清肌酐和NGAL显著更高。
我们的研究证实了青少年时期出生体重与血压之间存在性别依赖性的反比关系。早产组中较高的血清肌酐和NGAL可能表明早产会长期影响肾功能。
