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健康足月儿和稳定早产儿中性粒细胞明胶酶相关脂质运载蛋白、胱抑素C和骨桥蛋白的尿浓度：一项初步研究。

The Urinary Concentrations of Neutrophil Gelatinase-Associated Lipocalin, Cystatin C and Osteopontin in the Healthy Term and Stable Preterm Neonates: A Pilot Study.

作者信息

Kamianowska Monika, Kamianowska Aleksandra, Maciejczyk Mateusz, Kurowska Anna, Błażewicz Bożena, Rogowska Agnieszka Maria, Wasilewska Anna

机构信息

Department of Neonatology and Neonatal Intensive Care, Medical University of Bialystok, 15-174 Bialystok, Poland.

Department of Pediatrics and Nephrology, Medical University of Bialystok, 15-274 Bialystok, Poland.

出版信息

J Clin Med. 2023 Oct 13;12(20):6512. doi: 10.3390/jcm12206512.

DOI:10.3390/jcm12206512
PMID:37892649
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10607199/
Abstract

BACKGROUND

In neonates, the assessment of kidney function with serum creatinine is limited; therefore, more effective biomarkers are needed.

AIM

The study aimed at analyzing the concentrations of renal biomarkers (osteopontin, cystatin C, and NGAL) in neonates.

MATERIAL AND METHODS

The study included 80 term and 20 preterm neonates aged 28-33 weeks of gestation. Biomarkers were measured in urine. Term neonates' urine was collected on the 1st day of life. Preterm neonates' urine was collected on the 1st, 8th, 15th, 22nd day of life. Biomarkers' concentrations were normalized to urinary creatinine (cr.) and presented as urinary biomarker/cr. ratios.

RESULTS

Median values of biomarker/creatine ratios in term and preterm neonates were the following: cystatin C/cr.: 7.26 and 439.49; osteopontin/cr.: 135.86 and 1633.37; NGAL/cr. in girls: 212.14 and 256.93; and NGAL/cr. in boys 27.123 and 65.29 ng/mg cr. In preterm neonates the cystatin C/cr. ratio was higher on the 1st than on the 8th day. The osteopontin/cr. ratio did not differ between the days. The NGAL/cr. ratio in girls was higher on the 8th than on the 22nd day, and in boys, the lowest was on the 22nd day.

CONCLUSIONS

Prematurity in stable, Caucasian neonates might cause higher osteopontin and cystatin C excretion, but not NGAL. The excretion of NGAL and cystatin C, but not osteopontin, may change during first weeks of premature neonate's life.

摘要

背景

在新生儿中，利用血清肌酐评估肾功能存在局限性；因此，需要更有效的生物标志物。

目的

本研究旨在分析新生儿肾生物标志物（骨桥蛋白、胱抑素C和中性粒细胞明胶酶相关脂质运载蛋白）的浓度。

材料与方法

本研究纳入了80例足月儿和20例孕28 - 33周的早产儿。对尿液中的生物标志物进行检测。足月儿出生第1天收集尿液。早产儿在出生第1、8、15、22天收集尿液。将生物标志物浓度以尿肌酐进行标准化，并以尿生物标志物/肌酐比值表示。

结果

足月儿和早产儿生物标志物/肌酐比值的中位数如下：胱抑素C/肌酐：7.26和439.49；骨桥蛋白/肌酐：135.86和1633.37；女孩中性粒细胞明胶酶相关脂质运载蛋白/肌酐：212.14和256.93；男孩中性粒细胞明胶酶相关脂质运载蛋白/肌酐：27.123和65.29 ng/mg肌酐。在早产儿中，胱抑素C/肌酐比值在出生第1天高于第8天。骨桥蛋白/肌酐比值在各天之间无差异。女孩中性粒细胞明胶酶相关脂质运载蛋白/肌酐比值在第8天高于第22天，男孩则在第22天最低。

结论

稳定的白种人新生儿早产可能导致骨桥蛋白和胱抑素C排泄增加，但不会导致中性粒细胞明胶酶相关脂质运载蛋白排泄增加。早产儿出生后最初几周内，中性粒细胞明胶酶相关脂质运载蛋白和胱抑素C的排泄可能会发生变化，但骨桥蛋白不会。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6242/10607199/aa9028a7d3ed/jcm-12-06512-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6242/10607199/753e2daeb9e8/jcm-12-06512-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6242/10607199/3409af6113e9/jcm-12-06512-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6242/10607199/3da791674c5f/jcm-12-06512-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6242/10607199/3b620dce9c28/jcm-12-06512-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6242/10607199/aa9028a7d3ed/jcm-12-06512-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6242/10607199/753e2daeb9e8/jcm-12-06512-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6242/10607199/3409af6113e9/jcm-12-06512-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6242/10607199/3da791674c5f/jcm-12-06512-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6242/10607199/3b620dce9c28/jcm-12-06512-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6242/10607199/aa9028a7d3ed/jcm-12-06512-g005.jpg

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Clin Chim Acta. 2022 Nov 1;536:135-141. doi: 10.1016/j.cca.2022.08.029. Epub 2022 Sep 21.
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