Broscheid Kim-Charline, Hamacher Dennis, Lamprecht Juliane, Sailer Michael, Schega Lutz
Department of Sport Science, Institute III, Otto von Guericke University (OvGU) Magdeburg, Zschokkestraße 32, 39104 Magdeburg, Germany.
MEDIAN Neurological Rehabilitation Center Magdeburg, Gustav-Ricker-Straße 4, 39120 Magdeburg, Germany.
Brain Sci. 2020 Sep 17;10(9):643. doi: 10.3390/brainsci10090643.
Many established technologies are limited in analyzing the executive functions in motion, especially while walking. Functional near-infrared spectroscopy (fNIRS) fills this gap. The aim of the study is to investigate the inter-session reliability (ISR) of fNIRS-derived parameters at the prefrontal cortex while walking in people with multiple sclerosis (MS) and healthy control (HC) individuals. Twenty people with MS/HC individuals walked a 12 m track back and forth over 6 min. The primary outcomes were the absolute and relative reliability of the mean, slope coefficient (SC), and area under the curve (A) of the oxy-/deoxyhemoglobin concentrations (HbO/HbR) in the Brodmann areas (BA) 9/46/10. The SC and the A of HbO exhibited a fair ISR in BA10 in people with MS. For the mean and A of the HbR, almost all areas observed revealed a fair ISR. Overall, the ISR was better for HbR than HbO. A fair to excellent ISR was found for most BA of the prefrontal cortex in HC individuals. In total, the ISR of the analyzed fNIRS-derived parameters was limited. To improve the ISR, confounders such as fatigue and mind wandering should be minimized. When reporting the ISR, the focus should be on the mean/A rather than SC.
许多现有技术在分析运动中的执行功能时存在局限性，尤其是在行走时。功能近红外光谱技术（fNIRS）填补了这一空白。本研究的目的是调查多发性硬化症（MS）患者和健康对照（HC）个体在行走时前额叶皮层fNIRS衍生参数的会话间可靠性（ISR）。20名MS/HC个体在12米的轨道上来回行走6分钟。主要结果是布罗德曼区域（BA）9/46/10中氧合/脱氧血红蛋白浓度（HbO/HbR）的平均值、斜率系数（SC）和曲线下面积（A）的绝对和相对可靠性。在MS患者的BA10中，HbO的SC和A表现出较好的ISR。对于HbR的平均值和A，几乎所有观察区域都显示出较好的ISR。总体而言，HbR的ISR优于HbO。在HC个体的前额叶皮层的大多数BA中发现了较好到优秀的ISR。总的来说，分析的fNIRS衍生参数的ISR是有限的。为了提高ISR，应尽量减少疲劳和走神等混杂因素。在报告ISR时，重点应放在平均值/A而不是SC上。
