Department of Pathobiology and Population Sciences, The Royal Veterinary College, Hertfordshire, UK.
Department of Pathobiology and Population Sciences, The Royal Veterinary College, Hertfordshire, UK.
J Comp Pathol. 2020 Aug;179:1-6. doi: 10.1016/j.jcpa.2020.07.002. Epub 2020 Aug 7.
In humans, apocrine gland tumours encompass a heterogeneous group of uncommon neoplasms with varied and unpredictable biological behaviour. They can be slow-growing lesions, recur after excision, produce lymph node metastasis in up to 50% of cases or lead to tumour-related death. We document a malignant scent adenocarcinoma in a wedge-capped capuchin monkey (Cebus olivaceus). Immunohistochemical labelling revealed complete absence of myoepithelial cells, a finding usually considered a hallmark of malignancy in humans; however, after a 2-year follow-up, the neoplasm had not recurred. This is the first detailed report of the pathology of a spontaneous scent (apocrine) gland adenocarcinoma in a non-human primate.
在人类中，大汗腺肿瘤包含一组异质性的罕见肿瘤，具有不同和不可预测的生物学行为。它们可能是生长缓慢的病变，切除后会复发，多达 50%的病例会发生淋巴结转移，或导致与肿瘤相关的死亡。我们在一只楔形冠卷尾猴（Cebus olivaceus）中记录了一例恶性气味腺腺癌。免疫组织化学标记显示完全缺乏肌上皮细胞，这一发现通常被认为是人类恶性肿瘤的标志；然而，经过 2 年的随访，该肿瘤没有复发。这是首例关于非人类灵长类动物自发性气味（大汗腺）腺腺癌的详细病理学报告。
