细胞外囊泡在心脏再生中的作用：用于芯片上器官的潜在应用。
Extracellular Vesicles in Cardiac Regeneration: Potential Applications for Tissues-on-a-Chip.
机构信息
Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON, Canada; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada.
Department of Medicine, Columbia University, New York, NY, USA; Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
出版信息
Trends Biotechnol. 2021 Aug;39(8):755-773. doi: 10.1016/j.tibtech.2020.08.005. Epub 2020 Sep 19.
Strategies to regenerate cardiac tissue postinjury are limited and heart transplantation remains the only 'cure' for a failing heart. Extracellular vesicles (EVs), membrane-bound cell secretions important in intercellular signaling, have been shown to play a crucial role in regulating heart function. A mechanistic understanding of the role of EVs in the heart remains elusive due to the challenges in studying the native human heart. Tissue-on-a-chip platforms, comprising functional, physiologically relevant human tissue models, are an emerging technology that has yet to be fully applied to the study of EVs. In this review, we summarize recent advances in cardiac tissue-on-a-chip (CTC) platforms and discuss how they are uniquely situated to advance our understanding of EVs in cardiac disease and regeneration.
受伤后心脏组织的再生策略有限，心脏移植仍然是治疗衰竭心脏的唯一“方法”。细胞外囊泡 (EVs) 是细胞间信号传递中重要的膜结合细胞分泌物，已被证明在调节心脏功能方面发挥着关键作用。由于研究天然人类心脏的挑战性，EV 在心脏中的作用的机制理解仍然难以捉摸。组织芯片平台，由具有功能的、生理相关的人类组织模型组成，是一种新兴技术，尚未完全应用于 EV 的研究。在这篇综述中，我们总结了心脏组织芯片 (CTC) 平台的最新进展，并讨论了它们如何独特地推进我们对心脏疾病和再生中 EV 的理解。
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