Department of General Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, PR China.
Department of Pathology, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, PR China.
Biomark Med. 2020 Nov;14(16):1573-1584. doi: 10.2217/bmm-2020-0321. Epub 2020 Sep 22.
To evaluate the expression and clinicopathological significance of a disintegrin and metalloproteinases 19 (ADAM19) CUE domain containing protein 2 (CUEDC2) in extrahepatic cholangiocarcinoma (EHCC). Immunostaining of ADAM19 and CUEDC2 was performed by EnVision immunohistochemistry in benign and malignant biliary tract tissues. The expression of ADAM19 and CUEDC2 were significantly higher in EHCC (p < 0.05). ADAM19 expression was positive correlated with CUEDC2 expression in EHCC (p < 0.05). The overall survival time of those with positive expression of ADAM19 and CUEDC2 was lower (p < 0.001). Both positive expression of ADAM19 and CUEDC2 were independent prognostic factors in EHCC. ADAM19 and CUEDC2 have a positive correlation to the pathogenesis and dismal prognosis in EHCC.
评估解整合素金属蛋白酶 19（ADAM19）CUE 结构域包含蛋白 2（CUEDC2）在外胆管癌（EHCC）中的表达及其临床病理意义。通过 EnVision 免疫组织化学法在良性和恶性胆道组织中检测 ADAM19 和 CUEDC2 的表达。EHCC 中 ADAM19 和 CUEDC2 的表达显著升高（p < 0.05）。EHCC 中 ADAM19 的表达与 CUEDC2 的表达呈正相关（p < 0.05）。ADAM19 和 CUEDC2 阳性表达的患者总生存时间较低（p < 0.001）。ADAM19 和 CUEDC2 的阳性表达均为 EHCC 的独立预后因素。ADAM19 和 CUEDC2 与 EHCC 的发病机制和不良预后呈正相关。
