Food Additives and Packaging Division, National Institute of Food and Drug Safety Evaluation , Cheongju, Republic of Korea.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2020 Nov;37(11):1974-1984. doi: 10.1080/19440049.2020.1791974. Epub 2020 Sep 22.
A simple and novel method based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed and validated to determine the levels of 10 compounds (bisphenol A diglycidyl ether (BADGE), novolac-glycidyl ethers (NOGEs), and their related compounds) migrated from food and beverage cans into food simulants. Method validation showed acceptable linearity, precision, and accuracy. The detection limits ranged from 0.28 to 14.8 μg L, and the quantification limits ranged from 0.94 to 49.3 μg L. Water, 4% acetic acid, 50% ethanol, and heptane were employed as food simulants for the migration tests, and the developed LC-MS/MS method was applied to 104 epoxy-coated beverage and food metal cans. Only BADGE∙2HO and BADGE were detected; the levels were below the specific migration limit. Based on the obtained migration results, the estimated daily intakes (EDIs) of BADGE∙2HO and BADGE were calculated. Exposure assessments were conducted to compare the EDI with the tolerable daily intake (TDI), with a relatively low percentage of the TDI being reported. NOGE and its related compounds were not detected in the monitored cans. Long-term storage tests were also conducted at 60°C over 30 days. Only BADGE∙2HO was detected in all food simulants, except for heptane, and the maximum amount detected was 114.6 μg L in 50% ethanol.
建立并验证了一种基于液相色谱-串联质谱（LC-MS/MS）的简单新颖方法，用于测定从食品和饮料罐迁移到食品模拟物中的 10 种化合物（双酚 A 二缩水甘油醚（BADGE）、 novolac-缩水甘油醚（NOGE）及其相关化合物）的水平。方法验证表明具有可接受的线性、精密度和准确度。检测限范围为 0.28 至 14.8μg/L，定量限范围为 0.94 至 49.3μg/L。水、4%乙酸、50%乙醇和正庚烷被用作迁移测试的食品模拟物，所开发的 LC-MS/MS 方法应用于 104 个环氧涂层饮料和食品金属罐。仅检测到 BADGE∙2HO 和 BADGE；其水平低于特定迁移限量。基于获得的迁移结果，计算了 BADGE∙2HO 和 BADGE 的估计每日摄入量（EDI）。进行了暴露评估，将 EDI 与可耐受每日摄入量（TDI）进行了比较，报告的 TDI 相对较低。在监测的罐中未检测到 NOGE 及其相关化合物。还进行了为期 30 天、在 60°C 下的长期储存测试。除正庚烷外，在所有食品模拟物中均检测到 BADGE∙2HO，在 50%乙醇中检测到的最大量为 114.6μg/L。
