State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.
Analyst. 2020 Oct 26;145(21):6769-6812. doi: 10.1039/d0an01225d.
Enantioselective fluorescent sensors show large potential for fast, real-time, and highly sensitive measurement of the concentration and enantiomeric composition of chiral molecules. Among all of the sensors, BINOL-based sensors have been actively investigated and extensively used to carry out highly enantioselective, sensitive recognition of chiral α-hydroxycarboxylic acids, amino acids, amino acid derivatives, amino alcohols and amines. In this manuscript, the recent progress of chiral BINOL-based sensors for enantioselective fluorescence recognition of different substrates is reviewed and discussed. The structure of BINOL is tuned by introducing various groups or molecules which systematically changed its fluorescence properties and offered potential for rapid assays of chiral organic molecules. From the development of this area, we gain fresh insight into the challenges and chances of BINOL-based sensors.
对映选择性荧光传感器在快速、实时、高灵敏度地测量手性分子的浓度和对映体组成方面显示出巨大的潜力。在所有的传感器中，基于 BINOL 的传感器受到了积极的研究和广泛的应用，以实现对手性 α-羟基羧酸、氨基酸、氨基酸衍生物、氨基醇和胺的高度对映选择性、灵敏识别。在本文中，综述并讨论了基于手性 BINOL 的传感器对手性荧光识别不同底物的最新进展。通过引入各种基团或分子来调节 BINOL 的结构，系统地改变其荧光性质，为手性有机分子的快速分析提供了可能性。从这一领域的发展中，我们深入了解了基于 BINOL 的传感器所面临的挑战和机遇。
