用于α-羟基羧酸的基于联萘大环的高对映选择性荧光传感器。

Bisbinaphthyl macrocycle-based highly enantioselective fluorescent sensors for alpha-hydroxycarboxylic acids.

作者信息

Lin Jing, Zhang Hui-Chang, Pu Lin

机构信息

Department of Chemistry, University of Virginia, Charlottesville 22904-4319, USA.

出版信息

Org Lett. 2002 Sep 19;4(19):3297-300. doi: 10.1021/ol026565c.

DOI:10.1021/ol026565c

PMID:12227773

Abstract

[structure: see text] Bisbinaphthyl-based macrocycles are found to carry out highly enantioselective fluorescent recognition of alpha-hydroxycarboxylic acids. It is observed that within a certain concentration range, one enantiomer of the chiral acids can increase the fluorescence intensity of the macrocycles by 2-3-fold, while the other enantiomer scarcely enhances the fluorescence. Such unusually high enantioselective responses make these macrocycles very attractive as fluorescent sensors in determining the enantiomeric composition of alpha-hydroxycarboxylic acids.

摘要

[结构：见正文] 基于联二萘基的大环化合物被发现能够对α-羟基羧酸进行高度对映选择性荧光识别。据观察，在一定浓度范围内，手性酸的一种对映体可使大环化合物的荧光强度增强2至3倍，而另一种对映体几乎不增强荧光。这种异常高的对映选择性响应使得这些大环化合物作为荧光传感器在测定α-羟基羧酸的对映体组成方面极具吸引力。