论著名中药“附子”：强心成分新乌头碱的发现、研究与开发
On the Famous Traditional Chinese Medicine "Fu Zi": Discovery, Research, and Development of Cardioactive Constituent Mesaconine.
作者信息
Wang Feng-Peng, Chao Ruo-Bing
机构信息
Department of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University, Chengdu, 610041, People's Republic of China.
出版信息
Nat Prod Bioprospect. 2021 Feb;11(1):15-20. doi: 10.1007/s13659-020-00266-w. Epub 2020 Sep 22.
Abstract
This review summarizes the process of the discovery, research, and development of a cardioactive component, mesaconine, from the lateral roots of Aconitum carmichaelii ("Fu Zi"). To date, pre-clinical showed that mesaconine is a novel type of cardiotonic lead drug with relatively high potency, low toxicity, and a new mechanism.
摘要
本综述总结了从附子（“附子”）侧根中发现、研究和开发具有心脏活性的成分中乌头碱的过程。迄今为止，临床前研究表明，中乌头碱是一种新型强心先导药物，具有相对较高的效力、较低的毒性和新的作用机制。
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