Department of Translational Medical Science, Section of Pediatrics, "Federico II" University of Naples, Naples, Italy.
Department of Pediatrics, A.O.R.N. Santobono-Pausilipon, Via Mario Fiore 6, 80129, Naples, Italy.
J Endocrinol Invest. 2021 Jun;44(6):1275-1281. doi: 10.1007/s40618-020-01425-z. Epub 2020 Sep 22.
The main aim of the study was to assess the relationship between leptin, ghrelin, insulin-like growth factor 1 (IGF-1), and glucagon-like peptide 1 (GLP-1) blood levels and gastric motility in children with obesity compared to healthy children. Secondary aims were to assess the possible association between these hormones and obesity, reflux impedance parameters, reflux symptoms, other GI disorders, and quality-of-life scores within the same groups.
Children with obesity plus GERD symptoms and 2 control groups of children with obesity without GERD and healthy lean children aged 4-17 years underwent an auxological evaluation, an assessment of gastro-intestinal symptoms and quality of life, hormonal dosages, and an evaluation of gastric emptying time (GET) through 13C-octanoic acid breath test.
No significant association was found between hormones and gastric motility. Leptin and ghrelin levels were significantly associated with obesity parameters. No significant differences were found between GET and hormones of the patients with obesity, either with or without GERD.
Although we found an association between auxological parameters and both leptin and ghrelin levels, this association did not imply an effect on the upper GI motility. Therefore, our hypothesis that alterations of these hormones in children with obesity could affect gastric emptying, triggering GERD, was not supported by our data.
本研究的主要目的是评估肥胖儿童与健康儿童相比，瘦素、胃饥饿素、胰岛素样生长因子 1（IGF-1）和胰高血糖素样肽 1（GLP-1）的血液水平与胃动力之间的关系。次要目的是评估这些激素与肥胖、反流阻抗参数、反流症状、其他胃肠道疾病以及同一组内生活质量评分之间的可能关联。
4-17 岁患有肥胖症和 GERD 症状的儿童以及 2 组肥胖症但无 GERD 症状的对照组和健康瘦儿童接受了人体测量评估、胃肠道症状和生活质量评估、激素剂量以及通过 13C-辛酸呼吸试验评估胃排空时间（GET）。
未发现激素与胃动力之间存在显著相关性。瘦素和胃饥饿素水平与肥胖参数显著相关。肥胖症患者无论是否患有 GERD，其 GET 和激素之间均无显著差异。
尽管我们发现了生长参数与瘦素和胃饥饿素水平之间的关联，但这种关联并不意味着对上胃肠道动力有影响。因此，我们的假设，即肥胖儿童这些激素的改变可能会影响胃排空，从而引发 GERD，并没有得到我们数据的支持。
