Hauser B, Roelants M, De Schepper J, Veereman G, Caveliers V, Devreker T, De Greef E, Vandenplas Y
Department of Paediatrics, Universitair Kinderziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium.
Department of Public Health and Primary Care, Katholieke Universiteit Leuven, Leuven, Belgium.
Neurogastroenterol Motil. 2016 Oct;28(10):1480-7. doi: 10.1111/nmo.12845. Epub 2016 Apr 20.
(99m) Technetium scintigraphy ((99m) TS) is the 'gold standard' for measuring gastric emptying (GE), but it is associated with a radiation exposure. For this reason, the (13) C-octanoic acid breath test ((13) C-OBT) was developed for measuring GE of solids. The objective of this study was to determine normal values for gastric half-emptying time (t1/2 GE) of solids in healthy children.
Gastric emptying of a standardized solid test meal consisting of a pancake evaluated with (99m) TS and (13) C-OBT was compared in 22 children aged between 1 and 15 years with upper gastrointestinal symptoms. Subsequently, the (13) C-OBT was used to determine normal values for GE of the same solid test meal in 120 healthy children aged between 1 and 17 years.
The results showed a significant correlation (r = 0.748, p = 0.0001) between t1/2 GE measured with both techniques in the group of children with upper gastrointestinal symptoms. In the group of healthy children, mean t1/2 GE was 157.7 ± 54.0 min (range 71-415 min), but t1/2 GE decreased with age between 1 and 10 years and remained stable afterward. There was no influence of gender, weight, height, body mass index, and body surface area on t1/2 GE.
CONCLUSIONS & INFERENCES: Normal values for GE of solids measured with the (13) C-OBT using a standardized methodology were determined in healthy children. We propose to use this method and corresponding reference ranges to study GE of solids in children with gastrointestinal problems.
锝（99m）闪烁扫描法（（99m）TS）是测量胃排空（GE）的“金标准”，但它会带来辐射暴露。因此，开发了碳（13）辛酸呼气试验（（13）C - OBT）用于测量固体食物的胃排空。本研究的目的是确定健康儿童固体食物胃半排空时间（t1/2 GE）的正常值。
对22名年龄在1至15岁有上消化道症状的儿童，比较用（99m）TS和（13）C - OBT评估的由煎饼组成的标准化固体试验餐的胃排空情况。随后，用（13）C - OBT确定120名年龄在1至17岁健康儿童相同固体试验餐胃排空的正常值。
结果显示，在上消化道症状儿童组中，两种技术测量的t1/2 GE之间存在显著相关性（r = 0.748，p = 0.0001）。在健康儿童组中，平均t1/2 GE为157.7±54.0分钟（范围71 - 415分钟），但t1/2 GE在1至10岁之间随年龄下降，之后保持稳定。性别、体重、身高、体重指数和体表面积对t1/2 GE没有影响。
使用标准化方法通过（13）C - OBT确定了健康儿童固体食物胃排空的正常值。我们建议使用该方法和相应的参考范围来研究有胃肠道问题儿童的固体食物胃排空情况。
