1986 年至 2017 年美国空军战斗机飞行员和其他军官的恶性肿瘤发病情况：一项回顾性队列研究。

Malignancy in U.S. Air Force fighter pilots and other officers, 1986-2017: A retrospective cohort study.

机构信息

Public Health and Preventive Medicine Department, U.S. Air Force School of Aerospace Medicine, Wright-Patterson Air Force Base, Ohio, United States of America.

DataRev LLC, Atlanta, Georgia, United States of America.

出版信息

PLoS One. 2020 Sep 22;15(9):e0239437. doi: 10.1371/journal.pone.0239437. eCollection 2020.

DOI:10.1371/journal.pone.0239437

PMID:32960918

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7508357/

Abstract

OBJECTIVE

This study sought to determine the incidence rates of cancer, overall and by site, among active component U.S. Air Force fighter pilots, and to compare the rates with those in other active component Air Force officers.

METHODS

Using a matched retrospective cohort design, U.S. Air Force fighter pilots were compared with other commissioned officers who entered active component service between 1 January 1986 and 31 December 2006. The cohort was followed for cancer diagnoses in TRICARE and the Veterans Health Administration from 1 October 1995 through 31 December 2017. Fighter pilots and non-fighter pilot officers were compared after matching on sex, age at first observation (15 age groups), and age at last observation (15 age groups). Sex-stratified overall and site-specific cancer rates were compared with matched Poisson regression to determine incidence rate ratios with 95% confidence intervals.

RESULTS

During 1,412,590 person-years of follow-up, among the study population of 88,432 service members (4,949 fighter pilots and 83,483 matched officers), 977 incident cancer cases were diagnosed (86 in fighter pilots and 891 in matched officers). Male fighter pilots and matched officers had similar rates of all malignant cancers (RR = 1.04; 95% CI: 0.83-1.31) and of each cancer site. Female fighter pilots and matched officers also had similar rates of all malignant cancers (RR = 0.99; 95% CI: 0.25-4.04).

DISCUSSION

In the active component U.S. Air Force, fighter pilots and their officer peers had similar overall and site-specific cancer rates.

摘要

目的

本研究旨在确定现役美国空军战斗机飞行员的癌症总体发病率和部位发病率，并将这些发病率与其他现役空军军官进行比较。

方法

采用匹配回顾性队列设计，将美国空军战斗机飞行员与 1986 年 1 月 1 日至 2006 年 12 月 31 日期间入伍的其他现役空军军官进行比较。该队列从 1995 年 10 月 1 日至 2017 年 12 月 31 日期间，通过 TRICARE 和退伍军人健康管理局（Veterans Health Administration）跟踪癌症诊断情况。在按性别、首次观察时的年龄（15 个年龄组）和最后观察时的年龄（15 个年龄组）进行匹配后，对战斗机飞行员和非战斗机飞行员进行比较。采用匹配泊松回归比较性别分层的总体和部位特异性癌症发病率，以确定发病率比及其 95%置信区间。

结果

在 1,412,590 人年的随访期间，在研究人群 88,432 名军人中（4,949 名战斗机飞行员和 83,483 名匹配军官），诊断出 977 例癌症病例（86 例在战斗机飞行员中，891 例在匹配军官中）。男性战斗机飞行员和匹配军官的所有恶性癌症（RR = 1.04；95%CI：0.83-1.31）和每个癌症部位的发病率相似。女性战斗机飞行员和匹配军官的所有恶性癌症（RR = 0.99；95%CI：0.25-4.04）发病率也相似。