Department of Pharmaceutical Sciences, University of Perugia, via del Liceo 1, 06123, Perugia, Italy.
Department of Pharmacy, University of Napoli "Federico II", via D. Montesano 49, 80131, Napoli, Italy.
ChemMedChem. 2020 Dec 15;15(24):2391-2419. doi: 10.1002/cmdc.202000464. Epub 2020 Oct 22.
Infections by flaviviruses, such as Dengue, West Nile, Yellow Fever and Zika viruses, represent a growing risk for global health. There are vaccines only for few flaviviruses while no effective treatments are available. Flaviviruses share epidemiological, structural, and ecologic features and often different viruses can co-infect the same host. Therefore, the identification of broad-spectrum inhibitors is highly desirable either for known flaviviruses or for viruses that likely will emerge in the future. Strategies targeting both virus and host factors have been pursued to identify broad-spectrum antiflaviviral agents. In this review, we describe the most promising and best characterized targets and their relative broad-spectrum inhibitors, identified by drug repurposing/libraries screenings and by focused medicinal chemistry campaigns. Finally, we discuss about future strategies to identify new broad-spectrum antiflavivirus agents.
黄病毒（如登革热、西尼罗河、黄热病和寨卡病毒）感染对全球健康构成了日益严重的威胁。目前仅有少数几种黄病毒有疫苗可用，而没有有效的治疗方法。黄病毒具有流行病学、结构和生态特征，通常不同的病毒可以共同感染同一宿主。因此，无论是针对已知的黄病毒还是针对未来可能出现的病毒，寻找广谱抑制剂都是非常需要的。针对病毒和宿主因素的策略已经被用于寻找广谱抗黄病毒药物。在这篇综述中，我们描述了通过药物再利用/文库筛选和有针对性的药物化学研究确定的最有前途和特征最好的靶标及其相对广谱抑制剂。最后，我们讨论了识别新的广谱抗黄病毒药物的未来策略。
