Department of Pediatrics, Facuty of Medicine, Hacettepe University, Ankara, Turkey.
Özel Şan Med Hospital, Child Health and Disease Service, Şanlıurfa, Turkey.
Environ Toxicol Pharmacol. 2020 Nov;80:103502. doi: 10.1016/j.etap.2020.103502. Epub 2020 Sep 19.
Maternal milk is essential for optimum growth and development of an infant. The aim was to examine the presence of pharmaceutical residuals in breastmilk. This cohort study enrolled 90 healthy mother-infant pairs at 5-14 days after delivery and a control examination was performed 4-8 weeks later. Milk samples were taken at both visits. RANDOX Infiniplex kit performed residual analysis. More than half of mothers (54.4 %) had anti-inflammatory drug residues in at least one milk sample: those were 52.2 % for tolfenamic acid and 2.2 % for meloxicam and 1.1 % for metamizole. The most frequent residue group included the beta-lactam antibiotic group, which was detected in 93.3 % of mothers' milk. The second one was the quinolone group (81.1 %). One-third of mothers expressed nitroxynil and one-fifth polymyxin in at least one sample. Almost all mothers had some unexpected drug residues in their milk. Additional studies from other countries can display maternal environmental exposures.
母乳对于婴儿的最佳生长和发育至关重要。本研究旨在检测母乳中是否存在药物残留。该队列研究纳入了 90 对产后 5-14 天的健康母婴，并在 4-8 周后进行了对照检查。在两次就诊时均采集了奶样。使用 RANDOX Infiniplex 试剂盒进行残留分析。超过一半的母亲（54.4%）至少有一种奶样中存在抗炎药残留：托芬那酸占 52.2%，美洛昔康占 2.2%，氨基比林占 1.1%。最常见的残留药物组包括β-内酰胺类抗生素，在 93.3%的母亲的奶样中被检测到。其次是喹诺酮类（81.1%）。三分之一的母亲在至少一个样本中表达了硝西尼和五分之一的多粘菌素。几乎所有的母亲的奶样中都有一些意想不到的药物残留。来自其他国家的进一步研究可以揭示母亲的环境暴露情况。
