Department of Pediatrics, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Child Health and Disease Service, Özel Şan Med Hospital, Şanlıurfa, Turkey.
Hum Exp Toxicol. 2020 May;39(5):624-633. doi: 10.1177/0960327119898748. Epub 2020 Jan 13.
Melamine contamination is a recent public health problem emerging globally. Present study aimed to detect the rate of melamine presence in human milk in a cohort study and to evaluate any possible differences in maternal-infant pair characteristics such as breastfeeding status, crying and sleep problems of infants, maternal postpartum depression, maternal-infant bonding, infant and maternal anthropometry, and maternal complete blood count caused by the melamine exposure. Mothers of infants born in Şanlıurfa were invited to participate in 'Urfa Child Cohort Survey'. Overall, two breast milk samples were taken between 5 days and 15 days postpartum and between 4 weeks and 10 weeks. Randox Food's InfiniPlex array was used to analyse the presence of melamine. Melamine was detected in 32.2% and 24.4% of the first and the second milk samples; 16.7% of mothers had two positive samples. Scores for birth weight and scores for height for age were detected to be significantly lower in cases with two positive samples compared to cases with negative samples. Mean maternal white blood cells counts were found to be lower in cases with repeated melamine contact. Melamine might have a detrimental effect on birth weight, infant height and maternal blood count. Further studies should be done to detect environmental contamination in different regions and countries.
三聚氰胺污染是一个最近在全球范围内出现的公共卫生问题。本研究旨在通过队列研究检测人乳中三聚氰胺的存在率，并评估三聚氰胺暴露对母婴特征（如母乳喂养状况、婴儿哭闹和睡眠问题、产妇产后抑郁、母婴联系、婴儿和产妇人体测量以及产妇全血细胞计数）的可能影响。邀请出生在Şanlıurfa 的婴儿的母亲参加“乌尔法儿童队列研究”。总体而言，在产后 5 至 15 天和 4 至 10 周之间采集了两次母乳样本。Randox Food 的 InfiniPlex 阵列用于分析三聚氰胺的存在。在第一次和第二次母乳样本中分别检测到 32.2%和 24.4%的三聚氰胺；16.7%的母亲有两个阳性样本。与阴性样本相比，两个阳性样本的出生体重和身高年龄评分显著较低。有重复三聚氰胺接触的病例中，产妇的平均白细胞计数较低。三聚氰胺可能对出生体重、婴儿身高和产妇的血液计数有不利影响。应该在不同地区和国家开展进一步研究，以检测环境中的三聚氰胺污染。
