非核苷类抗病毒环丙基羧酸酰腙的合成及初步抗 HSV-1 构效关系研究。

Synthesis of non-nucleoside anti-viral cyclopropylcarboxacyl hydrazones and initial anti-HSV-1 structure-activity relationship studies.

机构信息

Department of Chemistry & Chemical Biology, McMaster University, Hamilton, Ontario L8S 4M1, Canada.

出版信息

Bioorg Med Chem Lett. 2020 Dec 15;30(24):127559. doi: 10.1016/j.bmcl.2020.127559. Epub 2020 Sep 19.

DOI:10.1016/j.bmcl.2020.127559

Abstract

The synthesis of a lead anti-viral cyclopropyl carboxy acyl hydrazone 4F17 (5) and three sequential arrays of structural analogues along with the initial assessment and optimization of the antiviral pharmacophore against the herpes simplex virus type 1 (HSV-1) are reported.

摘要

本文报道了一种先导抗病毒环丙基羧酰腙 4F17（5）的合成以及针对单纯疱疹病毒 1 型（HSV-1）的抗病毒药效团的初步评估和优化的三个连续结构类似物系列。