Swerdlow Neal R, Bhakta Savita G, Talledo Jo, Kotz Juliana, Roberts Benjamin Z, Clifford Royce Ellen, Thomas Michael L, Joshi Yash B, Molina Juan L, Light Gregory A
Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, CA, USA.
Department of Psychology, Colorado State University, Fort Collins, CO, USA.
Neuropsychopharmacology. 2020 Dec;45(13):2180-2188. doi: 10.1038/s41386-020-00865-8. Epub 2020 Sep 22.
The uncompetitive low-affinity NMDA receptor antagonist, memantine, acutely increases electrophysiological measures of auditory information processing in both healthy subjects (HS) and patients with schizophrenia. Memantine effects on functional measures of auditory discrimination performance and learning are not known; conceivably, beneficial effects on these measures might suggest a role for memantine in augmenting the cognitive and functional impact of auditory targeted cognitive training (TCT). Here, carefully characterized HS (n = 20) and schizophrenia patients (n = 22) were tested in measures of auditory discrimination performance (words-in-noise (WIN), quick speech-in-noise (QuickSIN), gaps-in-noise) and auditory frequency modulation learning (a component of TCT) on 2 days about a week apart, after ingesting either placebo or 20 mg memantine po, in a double-blind, within-subject cross-over random order design. Memantine modestly enhanced functional measures of auditory discrimination in both schizophrenia patients (WIN) and HS (WIN and QuickSIN), as well as auditory frequency modulation learning in schizophrenia patients. These findings converge with a growing literature showing that memantine can enhance a range of metrics of auditory function. These properties could contribute to the apparent benefits of memantine as an adjunctive treatment in schizophrenia, and suggest that memantine might augment learning and potentially clinical gains from auditory-based TCT.
非竞争性低亲和力N-甲基-D-天冬氨酸（NMDA）受体拮抗剂美金刚可急性增强健康受试者（HS）和精神分裂症患者的听觉信息处理的电生理指标。美金刚对听觉辨别性能和学习功能指标的影响尚不清楚；可以想象，对这些指标的有益影响可能表明美金刚在增强听觉靶向认知训练（TCT）的认知和功能影响方面发挥作用。在此，精心挑选的HS（n = 20）和精神分裂症患者（n = 22）在相隔约一周的两天内，在摄入安慰剂或口服20 mg美金刚后，按照双盲、受试者内交叉随机顺序设计，接受听觉辨别性能（噪声中的单词（WIN）、快速噪声中的语音（QuickSIN）、噪声中的间隙）和听觉频率调制学习（TCT的一个组成部分）的测试。美金刚适度增强了精神分裂症患者（WIN）和HS（WIN和QuickSIN）的听觉辨别功能指标，以及精神分裂症患者的听觉频率调制学习。这些发现与越来越多的文献一致，表明美金刚可以增强一系列听觉功能指标。这些特性可能有助于解释美金刚作为精神分裂症辅助治疗的明显益处，并表明美金刚可能增强基于听觉的TCT的学习以及潜在的临床获益。
