Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Clinical Research Unit, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Phytother Res. 2021 Feb;35(2):810-822. doi: 10.1002/ptr.6864. Epub 2020 Sep 22.
Mangiferin (MGF) is a polyphenolic C-glucosyl-xanthone extracted from the mango tree (Mangifera indica). MGF has shown diverse effects such as antioxidant, antiapoptotic, radical scavenging, and chelating properties. MGF also has been shown to modulate inflammatory pathways. In this review, we examined and evaluated the literature dealing with the protective effects of MGF against various chemical toxicities. Our literature review indicated that the MGF-induced protective effects against the toxic effects of pharmaceuticals, heavy metals and environmental chemicals were mainly mediated via suppression of lipid peroxidation, oxidative stress (along with enhancement of the antioxidant enzyme), inflammatory factors (TNF-α, IL-6, IL-10, and IL-12), and activation of PI3K/Akt and the MAPK survival signaling pathway.
芒果苷（MGF）是从芒果树（Mangifera indica）中提取的一种多酚 C-葡萄糖基黄烷酮。MGF 具有多种作用，如抗氧化、抗凋亡、清除自由基和螯合作用。MGF 还可以调节炎症途径。在这篇综述中，我们研究和评估了有关 MGF 对抗各种化学毒性的保护作用的文献。我们的文献综述表明，MGF 对药物、重金属和环境化学物质毒性的保护作用主要是通过抑制脂质过氧化、氧化应激（同时增强抗氧化酶）、炎症因子（TNF-α、IL-6、IL-10 和 IL-12）以及激活 PI3K/Akt 和 MAPK 生存信号通路来介导的。
