Dutta Tusheema, Das Tuyelee, Gopalakrishnan Abilash Valsala, Saha Suchismita Chatterjee, Ghorai Mimosa, Nandy Samapika, Kumar Manoj, Ghosh Arabinda, Mukerjee Nobendu, Dey Abhijit
Vanasiri Evolutionary Ecology Lab, School of Biology, IISER Thiruvananthapuram, Maruthamala, Vithura, Kerala, 695551, India.
Department of Life Sciences, Presidency University, 86/1 College Street, Kolkata, 700073, West Bengal, India.
Naunyn Schmiedebergs Arch Pharmacol. 2023 May;396(5):851-863. doi: 10.1007/s00210-022-02373-6. Epub 2023 Jan 19.
Mangiferin (1,3,6,7-tetrahydroxy-2-[3,4,5-trihydroxy-6-(hydroxymethyl) oxan-2-yl] xanthen-9-one) is a bioactive component derived primarily from the mango tree. Belonging to the Xanthone family, its structure allows it to engage with a variety of pharmacological targets. The symmetric linked core of xanthones has a heterogeneous biogenetic background. The carbon atoms are designated in a biochemical order, which reveals the reason of ring A (C1-C4) being referred to as acetate originated, and ring B (C5-C8) is referred to as shikimate originated. The antibacterial, hypocholesterolemic, antiallergic, cardiotonic, antidiabetic, anti-neoplastic, neuroprotective, antioxidant and immunomodulatory properties have all been demonstrated for the secondary metabolite. This study assessed and explained the important medical properties of mangiferin available in published literature, as well as its natural source, biosynthesis, absorption and bioavailability; multiple administration routes; metabolism; nanotechnology for enhanced efficacy of mangiferin and its toxicity, to aid the anticipated on-going potential of mangiferin as a novel diagnostic treatment.
芒果苷（1,3,6,7 - 四羟基 - 2 - [3,4,5 - 三羟基 - 6 - (羟甲基) 氧杂环己 - 2 - 基] 呫吨酮 - 9 - 酮）是一种主要源自芒果树的生物活性成分。它属于呫吨酮类家族，其结构使其能够与多种药理靶点相互作用。呫吨酮类的对称连接核心具有异质的生物合成背景。碳原子按生化顺序进行标注，这揭示了A环（C1 - C4）被称为源自乙酸酯，而B环（C5 - C8）被称为源自莽草酸酯的原因。这种次生代谢产物已被证明具有抗菌、降胆固醇、抗过敏、强心、抗糖尿病、抗肿瘤、神经保护、抗氧化和免疫调节特性。本研究评估并解释了已发表文献中关于芒果苷的重要医学特性，以及其天然来源、生物合成、吸收和生物利用度；多种给药途径；代谢；用于提高芒果苷疗效的纳米技术及其毒性，以助力芒果苷作为一种新型诊断治疗手段的预期潜在发展。
