School of Health Sciences, Universidade Positivo, Curitiba, Brazil.
Department of Stomatology, Universidade Federal do Paraná, Curitiba, Brazil.
Int J Paediatr Dent. 2021 Jan;31(1):152-163. doi: 10.1111/ipd.12721. Epub 2020 Oct 11.
Temporomandibular disorder (TMD) is a condition, in which multiple factors act synergistically to determine the outcome of the disorder.
A systematic review and meta-analysis was conducted to evaluate the association between genetic polymorphisms in catechol-O-methyltransferase (COMT) and TMD.
Observational studies that investigated this association were included. The risk of bias and study quality were evaluated according to the Newcastle-Ottawa tool. The meta-analysis was performed for each polymorphism associated with TMD signs and symptoms.
A total of 1903 articles were identified. Ten remained in the qualitative analysis: six were classified as low risk of bias and four with moderate risk of bias, and three were included in the meta-analysis. The polymorphism rs6269, in the genotypic model (0.65; CI = 0.44-0.97; P = .04) and in the allelic model (0.73; CI = 0.54-0.98; P = .04), was associated with myofascial pain. The rs9332377 was associated with myofascial pain in the genotypic model (2.69; CI = 1.51-4.76; P = .0007) and in the allelic model (1.46; CI = 1.01-2.13; P = .05) and with painful TMD in the genotypic model (2.08; CI = 1.27-3.40; P = .004) and in the allelic model (1.34 CI = 0.98-1.82; P = .06).
The polymorphisms in COMT were significantly associated with TMD.
颞下颌关节紊乱（TMD）是一种多因素协同作用决定疾病结局的病症。
进行系统评价和荟萃分析，以评估儿茶酚-O-甲基转移酶（COMT）基因多态性与 TMD 之间的关联。
纳入了研究这种关联的观察性研究。根据纽卡斯尔-渥太华工具评估了偏倚风险和研究质量。对与 TMD 体征和症状相关的每个多态性进行了荟萃分析。
共确定了 1903 篇文章。10 篇文章纳入定性分析：6 篇被归类为低偏倚风险，4 篇为中度偏倚风险，3 篇纳入荟萃分析。在基因型模型中（0.65；CI=0.44-0.97；P=0.04）和等位基因模型中（0.73；CI=0.54-0.98；P=0.04），rs6269 多态性与肌筋膜痛相关。rs9332377 与肌筋膜痛的基因型模型（2.69；CI=1.51-4.76；P=0.0007）和等位基因模型（1.46；CI=1.01-2.13；P=0.05）以及压痛性 TMD 的基因型模型（2.08；CI=1.27-3.40；P=0.004）和等位基因模型（1.34；CI=0.98-1.82；P=0.06）相关。
COMT 基因多态性与 TMD 显著相关。
