Freitag Nils, Doma Kenji, Neunhaeuserer Daniel, Cheng Sulin, Bloch Wilhelm, Schumann Moritz
Department of Molecular and Cellular Sport Medicine, Institute of Cardiovascular Research and Sport Medicine, German Sport University, Am Sportpark Müngersdorf 6, 50933 Cologne, Germany.
Sport and Exercise Science, College of Healthcare Sciences, James Cook University, Townsville, QLD 4811, Australia.
J Pers Med. 2020 Sep 19;10(3):135. doi: 10.3390/jpm10030135.
This systematic review aimed to explore the literature to identify in which types of chronic diseases exercise with supplemental oxygen has previously been utilized and whether this type of personalized therapy leads to superior effects in physical fitness and well-being. : Databases (PubMed/MEDLINE, CINHAL, EMBASE, Web of knowledge and Cochrane Library) were searched in accordance with PRISMA. Eligibility criteria included adult patients diagnosed with any type of chronic diseases engaging in supervised exercise training with supplemental oxygen compared to normoxia. A random-effects model was used to pool effect sizes by standardized mean differences (SMD). Out of the identified 4038 studies, 12 articles were eligible. Eleven studies were conducted in chronic obstructive pulmonary disease (COPD), while one study included coronary artery disease (CAD) patients. No statistical differences were observed for markers of physical fitness and patient-reported outcomes on well-being between the two training conditions (SMD -0.10; 95% CI -0.27, 0.08; = 0.26). We found that chronic exercise with supplemental oxygen has mainly been utilized for COPD patients. Moreover, no superior long-term adaptations on physical fitness, functional capacity or patient-reported well-being were found, questioning the role of this method as a personalized medicine approach. Prospero registration: CRD42018104649.
本系统评价旨在检索文献，以确定先前在哪些类型的慢性病中使用了补充氧气的运动，以及这种个性化治疗是否能在体能和幸福感方面产生更好的效果。根据PRISMA检索了数据库（PubMed/MEDLINE、CINHAL、EMBASE、Web of knowledge和Cochrane图书馆）。纳入标准包括诊断为任何类型慢性病的成年患者，与常氧相比，接受补充氧气的监督运动训练。采用随机效应模型，通过标准化均数差（SMD）汇总效应量。在检索到的4038项研究中，有12篇文章符合纳入标准。11项研究针对慢性阻塞性肺疾病（COPD）患者开展，1项研究纳入了冠状动脉疾病（CAD）患者。两种训练条件下，体能指标和患者报告的幸福感结局之间未观察到统计学差异（SMD -0.10；95% CI -0.27，0.08；P = 0.26）。我们发现，补充氧气的长期运动主要用于COPD患者。此外，未发现对体能、功能能力或患者报告的幸福感有更好的长期适应性，这对该方法作为一种个性化医疗方法的作用提出了质疑。Prospero注册号：CRD42018104649。
